April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Asymmetry in Structural Measures in the African Descent and Glaucoma Evaluation Study (ADAGES)
Grant H. Moore; Christopher Bowd; Jeffrey M. Liebmann; Christopher A. Girkin; Mauro T. Leite; Felipe A. Medeiros; Robert N. Weinreb; Linda M. Zangwill
Author Affiliations & Notes
  • Grant H. Moore
    NYU School of Medicine, New York, New York
    Ophthalmology, UCSD Hamilton Glaucoma Center, San Diego, California
  • Christopher Bowd
    Ophthalmology, UCSD Hamilton Glaucoma Center, San Diego, California
  • Jeffrey M. Liebmann
    Ophthalmology, New York Eye and Ear Infirmary, New York, New York
  • Christopher A. Girkin
    Ophthalmology, Univ of Alabama at Birmingham, Birmingham, Alabama
  • Mauro T. Leite
    Ophthalmology, UCSD Hamilton Glaucoma Center, San Diego, California
  • Felipe A. Medeiros
    Ophthalmology, UCSD Hamilton Glaucoma Center, San Diego, California
  • Robert N. Weinreb
    Ophthalmology, UCSD Hamilton Glaucoma Center, San Diego, California
  • Linda M. Zangwill
    Ophthalmology, UCSD Hamilton Glaucoma Center, San Diego, California
  • Footnotes
    Commercial Relationships  Grant H. Moore, None; Christopher Bowd, Pfizer Inc. (F); Jeffrey M. Liebmann, Alcon Laboratories Inc. (C), Allergan Inc. (C), Carl Zeiss Meditec (F), Dyopsis Corp. (F, C), Heidelberg Engineering (F), Optovue Inc. (F, C), Pfizer Inc. (C), Topcon Medical Systems Inc. (F, C); Christopher A. Girkin, Alcon Laboratories Inc. (C), Allergan Inc. (C), Carl Zeiss Meditec Inc. (R), Heidelberg Engineering Inc. (R), Merck Inc. (R), Optovue Inc. (R), Pfizer Inc. (C), Topcon Medical Systems Inc. (R); Mauro T. Leite, None; Felipe A. Medeiros, Alcon Laboratories Inc. (F, C, R), Allergan Inc. (C, R), Carl Zeiss Meditec Inc. (F, R), Merck Inc. (F), Pfizer Inc. (F, C, R), Reicherts Inc. (R); Robert N. Weinreb, Alcon Laboratories Inc. (C), Allergan Inc. (C), Carl Zeiss Meditec Inc. (F, C), Genetech Inc. (C), Heidelberg Engineering GmbH (F), Merck Inc. (C), Optovue Inc. (F, C), Pfizer Inc. (F, C), Topcon Medical Systems Inc. (F); Linda M. Zangwill, Carl Zeiss Meditec Inc. (F), Heidelberg Engineering GmbH (F, R), Optovue Inc. (F), Topcon Medical Systems Inc. (F)
  • Footnotes
    Support  NEI Grants U10EY14267, EY019869, EY08208, EY11008, and EY13959. Eyesight Foundation of Alabama; Alcon Laboratories Inc.; Allergan Inc.; Pfizer Inc.; Merck Inc.; Santen Inc.
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 206. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Asymmetry in Structural Measures in the African Descent and Glaucoma Evaluation Study (ADAGES)
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      Grant H. Moore, Christopher Bowd, Jeffrey M. Liebmann, Christopher A. Girkin, Mauro T. Leite, Felipe A. Medeiros, Robert N. Weinreb, Linda M. Zangwill; Asymmetry in Structural Measures in the African Descent and Glaucoma Evaluation Study (ADAGES). Invest. Ophthalmol. Vis. Sci. 2011;52(14):206.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : To compare the degree of inter-eye asymmetry of optic disc topography and retinal nerve fiber layer (RNFL) thickness in glaucoma patients of African descent (AD) and European descent (ED).

Methods: : 521 glaucoma patients with visual field defects, glaucomatous appearing optic discs or both (AD, n = 287, mean SAP MD =-4.04; ED, n = 234, mean SAP MD = -3.27) from the ADAGES and Diagnostic Innovations in Glaucoma Study (DIGS) were tested using HRT, GDx-VCC and SAP within 6 months of one another. HRT-II measurements included cup area, cup volume, rim area, rim volume, average cup depth, reference height, and rim to disk ratio. GDx-VCC measurements included average RNFL thickness. Inter-eye asymmetry was calculated as:Absolute Value ((OD Value- OS Value) / ((OD Value + OS Value) / 2))Asymmetry also was assessed in 475 healthy individuals (AD, n = 248; ED, n = 227), and 111 ocular hypertensives (AD, n = 51; ED, n = 60).

Results: : Asymmetry in AD glaucoma patients was significantly smaller than asymmetry in ED glaucoma patients for cup area (AD asymmetry = 0.279, ED asymmetry = 0.334, p = 0.0169) and cup volume (AD asymmetry = 0.419, ED asymmetry = 0.507, p = 0.0067). Asymmetry in AD patients was marginally larger than asymmetry in ED patients for average RNFL thickness (AD asymmetry = 0.103, ED asymmetry = 0.0856, p = 0.0532). Multivariate analyses including race, average optic disc area and glaucoma severity (defined as smallest SAP mean deviation OU) showed that significant race-related asymmetry remained for Cup Volume.

Conclusions: : Although ED glaucoma patients in general had more asymmetry than AD glaucoma patients, the difference in asymmetry by race, with the exception of cup volume, was reduced after adjusting for glaucoma severity and optic disc size.

Clinical Trial: : http://www.clinicaltrials.gov NCT00221923

Keywords: optic disc • imaging/image analysis: clinical 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept