April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Gdx-vcc Vs Gdx-ecc In Glaucoma Diagnosis
Author Affiliations & Notes
  • Giovanni Milano
    University Eye Clinic, University of Pavia, Pavia, Italy
  • Sara Lombardo
    University Eye Clinic, University of Pavia, Pavia, Italy
  • Laura Bossolesi
    University Eye Clinic, University of Pavia, Pavia, Italy
  • Marco Bordin
    University Eye Clinic, University of Pavia, Pavia, Italy
  • Marta Raimondi
    University Eye Clinic, University of Pavia, Pavia, Italy
  • Sara Lanteri
    University Eye Clinic, University of Pavia, Pavia, Italy
  • Gemma Maria Caterina Rossi
    University Eye Clinic, University of Pavia, Pavia, Italy
  • Footnotes
    Commercial Relationships  Giovanni Milano, None; Sara Lombardo, None; Laura Bossolesi, None; Marco Bordin, None; Marta Raimondi, None; Sara Lanteri, None; Gemma Maria Caterina Rossi, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 208. doi:https://doi.org/
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      Giovanni Milano, Sara Lombardo, Laura Bossolesi, Marco Bordin, Marta Raimondi, Sara Lanteri, Gemma Maria Caterina Rossi; Gdx-vcc Vs Gdx-ecc In Glaucoma Diagnosis. Invest. Ophthalmol. Vis. Sci. 2011;52(14):208. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : to compare results provided by scanning laser polarimetry variable corneal compensation (VCC) vs enhanced corneal compensation (ECC) and evaluate correlation to visual field results in glaucoma patients

Methods: : 339 eyes of 182 patients were included and screened by the glaucoma unit of the University Eye Clinic of Pavia (Italy). Patients were submitted to complete ophthalmic examination, standard automated perimetry (SAP), scanning laser polarimetry with GDx-VCC and GDx-ECC. Quality image (Q), typical scan score (TSS), nerve fibers index (NFI), nerve fibers layer average thickness in a band around the optic nerve head (TSNIT average) and in the upper (TSNIT sup) and lower sector (TSNIT inf) were evaluated for each exam. Q, TSS and morphometric parameters provided by VCC and ECC were compared using Wilcoxon signed-rank test and Lin concordance coefficient. Correlation between GDx and perimetric global indexes and was evaluated with Pearson correlation index

Results: : 204 images out of 339 (60%) were of good quality (Q>7) with VCC and 325 out of 339 (96%) with ECC. 140 images out of 339 (41%) were atypical (TSS<80) with VCC but only 20 out of 339 with ECC (6%). ECC vs VCC constantly displays lower TSNIT thickness and higher NFI. All comparisons between ECC and VCC parameters showed statistically significant differences confirmed by a moderate to poor concordance between the two instruments. Structure/function correlation was only poor to moderate and better for ECC parameters and first of all for NFI (0.6)

Conclusions: : ECC provides better quality images than VCC. High quality exam is the first condition to reproduce a more reliable RNFL structure. ECC points out lower RNFL thickness and higher NFI and reveal a better correlation to perimetric indexes MD and PSD as compared to VCC. GDx-ECC could improve early glaucoma diagnosis

Keywords: optic disc • imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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