April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
3T Diffusion Tensor MR Imaging Assessment Of Optic Nerve Correlates With GDx Vcc, HRT-III And Stratus OCT Indexes In Glaucoma Patients
Author Affiliations & Notes
  • Alessio Martucci
    Ophthalmology Unit,
    University of Rome Tor Vergata, Rome, Italy
  • Angelica Cerulli
    Ophthalmology Unit,
    University of Rome Tor Vergata, Rome, Italy
    Department of Pharmaco-Biology, University of Calabria, Cosenza, Italy
  • Raffaele Mancino
    Ophthalmology Unit,
    University of Rome Tor Vergata, Rome, Italy
  • Francesca Bolacchi
    Radiology Unit,
    University of Rome Tor Vergata, Rome, Italy
  • Claudio Cedrone
    Ophthalmology Unit,
    University of Rome Tor Vergata, Rome, Italy
  • Roberto Floris
    Radiology Unit,
    University of Rome Tor Vergata, Rome, Italy
  • Francesco G. Garaci
    Radiology Unit,
    University of Rome Tor Vergata, Rome, Italy
  • Carlo Nucci
    Ophthalmology Unit,
    University of Rome Tor Vergata, Rome, Italy
  • Footnotes
    Commercial Relationships  Alessio Martucci, None; Angelica Cerulli, None; Raffaele Mancino, None; Francesca Bolacchi, None; Claudio Cedrone, None; Roberto Floris, None; Francesco G. Garaci, None; Carlo Nucci, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 209. doi:
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      Alessio Martucci, Angelica Cerulli, Raffaele Mancino, Francesca Bolacchi, Claudio Cedrone, Roberto Floris, Francesco G. Garaci, Carlo Nucci; 3T Diffusion Tensor MR Imaging Assessment Of Optic Nerve Correlates With GDx Vcc, HRT-III And Stratus OCT Indexes In Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2011;52(14):209.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare the optic nerve axonal architecture assessed with diffusion-tensor magnetic resonance (DT-MR) imaging, with morphological data of the optic nerve head and the retinal nerve fiber layer (RNFL) obtained with HRT-III, GDx Vcc and Stratus OCT.

Methods: : Thirty six patients were examined: 24 were affected by primary open angle glaucoma (POAG) at different stages and 12 were normal subjects matched in age and sex. DT-MR imaging was performed with a 3-T MR unit and Mean Diffusivity (mMD) and Fractional Anisotropy (mFA) values were calculated for each optic nerve. The following clinical indexes were obtained from the three ophthalmological instruments. GDx Vcc: NFI, and meTSNIT. HRT-III: Disc Area, LCDR, RNFLt, Rim Area, Rim Volume, CSM, HVC, RB. OCT: avThickn. Their correlation with mMD and mFA were investigate by Pearson correlation matrix and by several multiple regression analysis.

Results: : The highest correlation was found between mMD and LCDR (r=0.662), followed by avThickn (r=-.644), and NFI (r=0.642), and between mFA and LCDR (r=-0.499), RimArea (r=-0.445), and NFI and RB (r=0.433). mMD correlated with: LCDR (p=0.02), considering all variables; avThickness (p < 0.01), considering retinal fiber layer parameters; NFI (p<0.01), considering GDx parameters; avThickn (p< 0.01), considering OCT parameters; LCDR (p = 0.01), considering HRT-III morphometric parameters; RB (p = 0.02), considering HRT-III indexes. mFA correlated with: avThickn (p=0.02), considering OCT parameters; RB (p=0.01), considering HRT-III indexes.

Conclusions: : Our study documents a significant correlation between axonal architecture of the optic nerves captured with DTi technology and morphological parameters obtained with GDx Vcc, HRT-III and OCT. This data suggest that DTi parameters can represent novel biomarkers of glaucoma severity and progression and may represent an adjunctive tool to asses neuroprotective properties of novel compounds.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • optic nerve • nerve fiber layer 
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