April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
The Effect Of Beclomethasone On Intraocular Pressure In Ocular Hypertension Or Controlled Glaucoma
Author Affiliations & Notes
  • Graham E. Trope
    Ophthalmology/Toronto Western Hospital, University Toronto, Toronto, Ontario, Canada
  • Darana Yuen
    Ophthalmology/Toronto Western Hospital, University Toronto, Toronto, Ontario, Canada
  • Yaping P. Jin
    Ophthalmology & Vis Sci,
    University of Toronto, Toronto, Ontario, Canada
  • Tariq A. Alasbali
    Ophthalmology, University of Dammam, Alkhubar, Saudi Arabia
  • Yvonne M. Buys
    Dept of Ophthalmology & Vision Sciences,
    University of Toronto, Toronto, Ontario, Canada
  • Footnotes
    Commercial Relationships  Graham E. Trope, None; Darana Yuen, None; Yaping P. Jin, None; Tariq A. Alasbali, None; Yvonne M. Buys, None
  • Footnotes
    Support  Departmental internal funding
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 213. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Graham E. Trope, Darana Yuen, Yaping P. Jin, Tariq A. Alasbali, Yvonne M. Buys; The Effect Of Beclomethasone On Intraocular Pressure In Ocular Hypertension Or Controlled Glaucoma. Invest. Ophthalmol. Vis. Sci. 2011;52(14):213.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : Steroid medications have been associated with increased intraocular pressure (IOP). Up to 35% of the general population and up to 90% of patients with primary open-angle glaucoma (POAG) are steroid responders. Allergic and non-allergic rhinitis affects millions of adults in North America. Topical nasal steroids are the most effective treatment option. Studies evaluating the effect of nasal steroids in glaucoma patients are limited. The purpose of our study was to evaluate the effect of 6 weeks of nasal steroids on ocular hypertension (OHT) or controlled POAG patients with or without rhinitis.

Methods: : Prospective randomized double-masked controlled trial. Inclusion criteria included the following: age 18-85 years; mild to moderate POAG with cup-disc ratio of <0.8 vertically and mean deviation of 20% from baseline. A sample size calculation indicated that 8 patients in each arm would be required to detect a difference of 3.2 mmHg with a power of 80%.

Results: : 19 consecutive consenting subjects completed the study-- 9 in the steroid arm and 10 in the placebo arm. There were no statistically significant differences between groups in baseline characteristics, IOP at each study visit, or change in IOP from baseline at any time point. At 6 weeks the change in mean IOP from baseline was +0.50 ± 1.52 versus +0.70 ± 1.44 mmHg in the steroid and saline nasal spray groups respectively (p=0.77).

Conclusions: : OHT and POAG subjects showed no evidence of IOP elevation following 6 weeks use of beclomethasone nasal spray.

Clinical Trial: : http://www.clinicaltrials.gov NCT00775489

Keywords: intraocular pressure 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×