Purchase this article with an account.
Graham E. Trope, Darana Yuen, Yaping P. Jin, Tariq A. Alasbali, Yvonne M. Buys; The Effect Of Beclomethasone On Intraocular Pressure In Ocular Hypertension Or Controlled Glaucoma. Invest. Ophthalmol. Vis. Sci. 2011;52(14):213.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Steroid medications have been associated with increased intraocular pressure (IOP). Up to 35% of the general population and up to 90% of patients with primary open-angle glaucoma (POAG) are steroid responders. Allergic and non-allergic rhinitis affects millions of adults in North America. Topical nasal steroids are the most effective treatment option. Studies evaluating the effect of nasal steroids in glaucoma patients are limited. The purpose of our study was to evaluate the effect of 6 weeks of nasal steroids on ocular hypertension (OHT) or controlled POAG patients with or without rhinitis.
Prospective randomized double-masked controlled trial. Inclusion criteria included the following: age 18-85 years; mild to moderate POAG with cup-disc ratio of <0.8 vertically and mean deviation of 20% from baseline. A sample size calculation indicated that 8 patients in each arm would be required to detect a difference of 3.2 mmHg with a power of 80%.
19 consecutive consenting subjects completed the study-- 9 in the steroid arm and 10 in the placebo arm. There were no statistically significant differences between groups in baseline characteristics, IOP at each study visit, or change in IOP from baseline at any time point. At 6 weeks the change in mean IOP from baseline was +0.50 ± 1.52 versus +0.70 ± 1.44 mmHg in the steroid and saline nasal spray groups respectively (p=0.77).
OHT and POAG subjects showed no evidence of IOP elevation following 6 weeks use of beclomethasone nasal spray.
Clinical Trial: :
This PDF is available to Subscribers Only