April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Increased Body Mass Index is Associated with Elevated Cerebrospinal Fluid Pressure
Author Affiliations & Notes
  • John P. Berdahl
    Ophthalmology, Vance Thompson Vision, Sioux Falls, South Dakota
  • David Fleischman
    Medicine & Ophthalmology, University of North Carolina Hospitals, Chapel Hill, North Carolina
  • Sandra S. Stinnett
    Ophthalmology, Duke University Eye Center, Durham, North Carolina
  • R R. Allingham
    Ophthalmology, Duke University Eye Center, Durham, North Carolina
  • Michael P. Fautsch
    Ophthalmology, Mayo Clinic, Rochester, Minnesota
  • Footnotes
    Commercial Relationships  John P. Berdahl, None; David Fleischman, None; Sandra S. Stinnett, None; R. R. Allingham, None; Michael P. Fautsch, None
  • Footnotes
    Support  NEI Grants: EY07065 (MPF) and EY15736 (MPF)
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 244. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      John P. Berdahl, David Fleischman, Sandra S. Stinnett, R R. Allingham, Michael P. Fautsch; Increased Body Mass Index is Associated with Elevated Cerebrospinal Fluid Pressure. Invest. Ophthalmol. Vis. Sci. 2011;52(14):244.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : Decreased body mass index (BMI) is a possible risk factor for primary open angle glaucoma (POAG). Low cerebrospinal fluid pressure (CSFP) is also a possible risk factor for POAG, while elevated CSFP may be protective. The aim of this study is to investigate if BMI and CSFP are related.

Methods: : Retrospectively extracted records of 4,800 patients who underwent diagnostic lumbar puncture at the Mayo Clinic (Rochester, MN) from 1996 to 2009 were examined. Exclusion criteria included diagnoses, surgical procedures or medications known to affect CSFP. The remaining patients’ CSFP results were recorded and categorized by unit of BMI. Mean CSFP for each unit BMI was calculated.

Results: : At BMI of 18, the mean CSFP is 112.9 mm H2O ± 48.7. By BMI of 21, there is a sustained and statistically significant increase in mean CSFP (124.4 mm H2O ± 42.5; p<0.05) that continues to a BMI of 35 (165.89 mm H2O ± 54.43; p<0.0001). Percent increase in CSFP from BMI of 18 to BMI of 35 was 32.4%.

Conclusions: : Our findings suggest that as BMI increases, CSFP increases. Under the premise that low CSFP may be a risk factor for developing glaucoma, and elevated CSFP may be protective, this study indirectly suggests that an elevated BMI may protect against POAG due to a corresponding increase in CSFP and is consistent with recent studies.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment • optic nerve • lamina cribrosa 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.