April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Effects of Coenzyme Q10 on Retinal and Cortical Evoked Responses in Patients with Open Angle Glaucoma
Vincenzo Parisi; Marco Centofanti; Stefano A. Gandolfi; Dario Marangoni; Luca M. Rossetti; Mariagrazia Tardini; Salvatore Traina; NIcola Ungaro; Michele Vetrugno; Benedetto Falsini
Author Affiliations & Notes
  • Vincenzo Parisi
    GB Bietti Eye Foundation-IRCCS, Rome, Italy
  • Marco Centofanti
    GB Bietti Eye Foundation-IRCCS, Rome, Italy
    Ophthalmology, University of Rome Tor Vergata, Rome, Italy
  • Stefano A. Gandolfi
    Ophthalmology, University of Parma, Parma, Italy
  • Dario Marangoni
    Ophthalmology, Catholic University, Rome, Italy
  • Luca M. Rossetti
    Eye Clinic, University of Milan, Milan, Italy
  • Mariagrazia Tardini
    Ophthalmology, University of Parma, Parma, Italy
  • Salvatore Traina
    Ophthalmology, Catholic University, Rome, Italy
  • NIcola Ungaro
    Ophthalmology, University of Parma, Parma, Italy
  • Michele Vetrugno
    Ophthalmology, Clinica Oculistica di Bari, Bari, Italy
  • Benedetto Falsini
    Ophthalmology, Catholic University, Rome, Italy
  • Footnotes
    Commercial Relationships  Vincenzo Parisi, None; Marco Centofanti, None; Stefano A. Gandolfi, None; Dario Marangoni, None; Luca M. Rossetti, None; Mariagrazia Tardini, None; Salvatore Traina, None; NIcola Ungaro, None; Michele Vetrugno, None; Benedetto Falsini, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 255. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Effects of Coenzyme Q10 on Retinal and Cortical Evoked Responses in Patients with Open Angle Glaucoma
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      Vincenzo Parisi, Marco Centofanti, Stefano A. Gandolfi, Dario Marangoni, Luca M. Rossetti, Mariagrazia Tardini, Salvatore Traina, NIcola Ungaro, Michele Vetrugno, Benedetto Falsini; Effects of Coenzyme Q10 on Retinal and Cortical Evoked Responses in Patients with Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2011;52(14):255.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : To evaluate the retinal function, the visual cortical responses and the neural conduction along the post-retinal visual pathways after treatment with Coenzyme Q10 in patients with open angle glaucoma (OAG).

Methods: : The results of 38 patients with OAG (mean age 51.8±3.7 ys, IOP < 18 mmHg with topical treatment, Mean Deviation of Humphrey 24-2 perimetry > -10 dB) were retrospectively evaluated. Simultaneous recordings of Pattern Electroretinogram (PERG) and Visual Evoked Potentials (VEPs) 1 were recorded at baseline and 6 and 12 months after treatment with Coenzyme Q10 and Vitamin E TPGS (Coqun ®, Visufarma, Italy, 2 drops 1 time/day, 22 eyes, GC Group), after treatment with Vitamin E TPGS (2 drops 1 time/day, 21 eyes GE Group) and after treatment with physiological solution (2 drops 1 time/day, 19 eyes, GP Group). Simultaneous recordings of PERG and VEP allow us to derive an electrophysiological index of post-retinal neural conduction that is called "Retinocortical Time (RCT)" 1.

Results: : At baseline conditions, similar values of PERG and VEP parameters (ANOVA, P>0.05) in GC, GE and GP eyes were observed. After 6 and 12 months of treatment, GE and GP eyes showed non significant (P>0.05) differences in PERG and VEP responses with respect to baseline conditions. In GC eyes it was observed a shortening in PERG P50 and VEP P100 implicit times and an increase in PERG P50-N95 and VEP N75-P100 amplitudes and the differences in implicit times and in amplitudes with respect to the baseline condition were significantly different (P<0.01) with respect to GE and GP ones. RCT was unmodified (P>0.05) in GC, GE and GP eyes.

Conclusions: : The results of this retrospective study suggest that Coenzyme Q10 treatment induces an improvement in retinal function as suggested by the enhancement in PERG responses. In presence of unchanged post-retinal neural conduction (unmodified RCT), the detected improvement in visual cortical responses (VEP enhancement) can be exclusively ascribed to the effect of Coenzyme Q10 in the retinal structures.1Parisi et al., IOVS 2010 Oct;51(10):5041-8.

Keywords: electrophysiology: clinical • visual impairment: neuro-ophthalmological disease • clinical research methodology 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept