Purchase this article with an account.
Vincenzo Parisi, Marco Centofanti, Stefano A. Gandolfi, Dario Marangoni, Luca M. Rossetti, Mariagrazia Tardini, Salvatore Traina, NIcola Ungaro, Michele Vetrugno, Benedetto Falsini; Effects of Coenzyme Q10 on Retinal and Cortical Evoked Responses in Patients with Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2011;52(14):255.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate the retinal function, the visual cortical responses and the neural conduction along the post-retinal visual pathways after treatment with Coenzyme Q10 in patients with open angle glaucoma (OAG).
The results of 38 patients with OAG (mean age 51.8±3.7 ys, IOP < 18 mmHg with topical treatment, Mean Deviation of Humphrey 24-2 perimetry > -10 dB) were retrospectively evaluated. Simultaneous recordings of Pattern Electroretinogram (PERG) and Visual Evoked Potentials (VEPs) 1 were recorded at baseline and 6 and 12 months after treatment with Coenzyme Q10 and Vitamin E TPGS (Coqun ®, Visufarma, Italy, 2 drops 1 time/day, 22 eyes, GC Group), after treatment with Vitamin E TPGS (2 drops 1 time/day, 21 eyes GE Group) and after treatment with physiological solution (2 drops 1 time/day, 19 eyes, GP Group). Simultaneous recordings of PERG and VEP allow us to derive an electrophysiological index of post-retinal neural conduction that is called "Retinocortical Time (RCT)" 1.
At baseline conditions, similar values of PERG and VEP parameters (ANOVA, P>0.05) in GC, GE and GP eyes were observed. After 6 and 12 months of treatment, GE and GP eyes showed non significant (P>0.05) differences in PERG and VEP responses with respect to baseline conditions. In GC eyes it was observed a shortening in PERG P50 and VEP P100 implicit times and an increase in PERG P50-N95 and VEP N75-P100 amplitudes and the differences in implicit times and in amplitudes with respect to the baseline condition were significantly different (P<0.01) with respect to GE and GP ones. RCT was unmodified (P>0.05) in GC, GE and GP eyes.
The results of this retrospective study suggest that Coenzyme Q10 treatment induces an improvement in retinal function as suggested by the enhancement in PERG responses. In presence of unchanged post-retinal neural conduction (unmodified RCT), the detected improvement in visual cortical responses (VEP enhancement) can be exclusively ascribed to the effect of Coenzyme Q10 in the retinal structures.1Parisi et al., IOVS 2010 Oct;51(10):5041-8.
This PDF is available to Subscribers Only