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Ted Maddess, Jr., Christian J. Lueck, Cristian Voicu, Andrew C. James; Multifocal Objective Pupil Perimetry (mfpop) In Ms. Invest. Ophthalmol. Vis. Sci. 2011;52(14):267. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the diagnostic power of a multifocal pupillographic perimeter, the TrueField Analyser (TFA), in multiple sclerosis (MS) patients who had different histories of acute neuritis.
METHODS: 35 normal (47.9 ± 16.8 yr, 22 women) and 85 MS subjects (49.8 ± 11.3 yr, 62 women) were enrolled; including 2 primary and 11 secondary progressives (PS), the remainder relapsing remitting (RR). EDSS scores for RR patients were 3.53 ± 1.04 (mean ± SD), and 5.90 ± 1.43 for PS. The TFA stimuli tested 44 regions/eye within the central 60 deg. The dichoptic sparse stimuli were delivered at a mean rate of 1/s/visual field region and each persisted for 33 ms on each presentation. Stimulus duration was 4 min divided into 8 intervals of 30 s.
ROC plots revealed that the percent area under ROC plots (%AUC) for the 144 RR eyes was 75.0 ± 3.31 (mean ± SE) and for the 26 PS eyes 94.8 ± 3.55 (mean EDSS 5.90 ± 1.43). %AUC for RRMS with EDSS >= 5 (5.29 ± 0.57) was 91.4 ± 8.1. For RR patients that had or had not experienced ON %AUC was 75.7 ± 4.48 and 75.4 ± 3.84 respectively.
Neither ON, nor a history of RR attacks had a significant effect on diagnostic power: and both RR and PS patients had %AUC consistent with EDSS scores. Take together these results suggested that the results were more dependent on "secondary" degeneration than inflammation history. Since both visual fields were examined concurrently separate direct and consensual fields are obtained for both eyes in 2 min/eye. This can permit afferent and efferent defects to be discriminated [IOVS 2010 51; 602-8].
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