April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Effects Of Occupational Exposure To A Solvent Mixture On Chromatic And Achromatic Vision Of Gas Station Workers
Author Affiliations & Notes
  • Thiago L. Costa, Sr.
    Psychology, Universidade de Sao Paulo, Sao Paulo SP, Brazil
  • Mirella T. Barboni
    Neuroscience and Behavior, University of Sao Paulo, Vinhedo, Brazil
  • Mirella Gualtieri
    Experimental Psychology, University of Sao Paulo, Sao Paulo, Brazil
  • Ana L. Moura
    Department of Psychology, Universidade de Sao Paulo, Sao Paulo, Brazil
  • Luiz Carlos L. Silveira
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
  • Dora F. Ventura
    Experimental Psychology, University of Sao Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships  Thiago L. Costa, Sr., None; Mirella T. Barboni, None; Mirella Gualtieri, None; Ana L. Moura, None; Luiz Carlos L. Silveira, None; Dora F. Ventura, None
  • Footnotes
    Support  CNPq, FAPESP
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 268. doi:
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      Thiago L. Costa, Sr., Mirella T. Barboni, Mirella Gualtieri, Ana L. Moura, Luiz Carlos L. Silveira, Dora F. Ventura; Effects Of Occupational Exposure To A Solvent Mixture On Chromatic And Achromatic Vision Of Gas Station Workers. Invest. Ophthalmol. Vis. Sci. 2011;52(14):268.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate the visual outcome of chronic occupational exposure to a mixture of organic solvents in a group of gas station workers.

Methods: : We tested 25 workers (20 male; age=36,4±8,9 years) and 25 controls with no history of chronic exposure to solvents (10 male; age=33,8±8,8 years). All participants had normal visual acuity and no ophthalmological complaints. Urinary concentrations of toluene (M=0,3±0,16g/g of creatinine) and xylene metabolites (M=0,1 g/g of creatinine), were within safe limits. Time of exposure was (M=9,6±6,2 years), used as indicators of the exposure. Color vision was evaluated with the Lanthony D15d and Cambridge Colour Test (CCT). Visual field were assessed with automatic white-on-white 24-2 perimetry (Humphrey II-750i). mfVEP were assessed in three workers (Veris Science 5.2.4). Contrast sensitivity (Metropsis software) was measured with sine wave gratings of 0,2; 0,5; 1,0; 2,0; 5,0; 10,0 and 20,0 cpd. The groups were compared using the Mann-Whitney U test.

Results: : In the CCT, there were significant differences for the area of the ellipse, elipticity and thresholds for the protan, deutan and tritan confusion axes (p<0,05). Significant differences between the groups were also found for the D15d (p<0,01) and for the automated perimetry results for the 9o, 15o and 21o eccentricity rings (p<0,05), MD and PSD (p<0,05). Each subject from the workers group showed at least 30 sectors of the visual field with significantly reduced amplitude (p<0,05) in the mfVEP when compared to normative data, while control group subjects had a maximum of 16 sectors of reduced amplitude. Significant correlation was found between time of work and deutan axis thresholds (π=0,59; p<0,05), indexes of the Lanthony D15d (π=0,52; p<0,05), perimetry results in the Fovea (π=-051; p<0,05) and at 3, 9 and 15 degrees of eccentricity (π=-0,46; p<0,05).

Conclusions: : Losses in visual function were found for chronic exposure to organic solvents even at exposures within occupational safety limits. The visual changes found were extensive and diffuse.

Keywords: contrast sensitivity • color vision • electrophysiology: clinical 

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