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Ari Kamei, Shigeki Machida, Eiichiro Nagasaka; Multifocal Photopic Negative Response (mfPhNR) and Lineal Visual Sensitivity in Patients with Optic Nerve Lesions. Invest. Ophthalmol. Vis. Sci. 2011;52(14):273.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the interrelation of mfPhNR and lineal visual sensitivity in the superior and inferior region in patients with optic nerve lesions.
Thirteen eyes of thirteen volunteers with normal vision and twenty eyes of ten patients with optic nerve lesions including normal tension glaucoma (NTG) were tested. The mfPhNR was recorded with the VERIS Science System 5.0.4. The visual stimulus was made up of 37 hexagons in an approximately 40-degree visual field, Pseudo-randomly alternating between black (5cd/m2) and white (200cd/m2) on the CRT monitor. Burian-Allen ERG Electrodes, Adult-bipolar or Pediatric-bipolar, were used for this testing. The recording time was approximately 8 min. with dilated pupils having the best-corrected visual acuity. The band pass filter of the amplifier was set from 1 to 100 Hz. The amplification and stimulus frequency were set to 10000 and 9.41 Hz (8 frames) respectively. Each trace of the mfPhNR found in all the superior and inferior regions was analyzed. The static visual field was examined with a central 30-2 SITA Standard program using a Humphrey Field Analyzer. The mean deviation (dB) was converted to lineal visual sensitivity (1/Lambert) to apply for the analysis.
There was a correlation between the amplitude of the mfPhNR in the superior region and lineal visual sensitivity in the superior visual field (R=0.421457, P=0.01712). There was also a correlation between the amplitude of the mfPhNR in the inferior region and lineal visual sensitivity in the inferior quadrant (R=0.504345, P=0.004331).
We presented previously that there was a correlation between the amplitude of mfPhNR and retinal nerve fiber layer thickness (RNFLT). The correlation between the amplitude of the mfPhNR and lineal visual sensitivity was less than the correlation between the amplitude of the mfPhNR and RNFLT.
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