April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Flash Visual Evoked Potentials: Maturation from Birth to 15 years of Age
Author Affiliations & Notes
  • Frederic Nicot
    Ophthalmology, CHU Dijon, Dijon, France
  • Roberto Flores Guevara
    Pediatric Neurophysiology Unit, Hôpital Armand-Trousseau, Paris, France
  • Alain Bron
    Ophthalmology, CHU Dijon, Dijon, France
  • Catherine Creuzot-Garcher
    Ophthalmology, CHU Dijon, Dijon, France
  • Francis Renault
    Pediatric Neurophysiology Unit, Hôpital Armand-Trousseau, Paris, France
  • Footnotes
    Commercial Relationships  Frederic Nicot, None; Roberto Flores Guevara, None; Alain Bron, None; Catherine Creuzot-Garcher, None; Francis Renault, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 399. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Frederic Nicot, Roberto Flores Guevara, Alain Bron, Catherine Creuzot-Garcher, Francis Renault; Flash Visual Evoked Potentials: Maturation from Birth to 15 years of Age. Invest. Ophthalmol. Vis. Sci. 2011;52(14):399.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : Visual evoked potentials (VEP) are frequently a relevant diagnostic test in pediatric ophthalmology and neurology. Recording VEP using reversal-pattern stimulus is not suitable for newborn and young infants because of the lack of visual attention. Flash VEP can be routinely performed even in the very young or uncooperative older child. We describe normal VEP in healthy children during development.

Methods: : Binocular VEP were performed in 126 healthy subjects from birth at term to 15 years of age classified into four age groups: (1), 3-120 days; (2), 121-365 days; (3), 1-3 years; (4), 3-15 years. VEP were recorded using scalp electrodes (O1 and O2, actives; Fz, reference; Cz, cephalic ground) in the conscious child with eyes open without sedation. Stimulus was a white flash (color temperature 5600°K, energy at source 0.3J) applied in a room with a background light of 0.55 lux. Evoked responses to 150 consecutive flashes delivered at 1 Hz were averaged. Analysis was performed manually and focused on the percentage of presence and the latencies of the successive negative (N) and positive (P) peaks of the waveform.

Results: : In group 1, P190ms was the main component, present in 80% of the subjects. Earlier components (N50, P65, N79, and P110) were less frequent (40-60%). In group 2, N175 was the main component, present in 90% of the subjects. Early components were obtained in 80% of the subjects, with shorter latencies: N41, P51, N72, and P99. In group 3, the percentage of presence of N40 and P51 waves increased (90 and 85% respectively). In group 4, P95 became the most easily recognizable and more frequently obtained component.

Conclusions: : Flash VEP can be carried out within a short investigating session using a protocol suitable for the very young. This test can be routinely used to evaluate the functional maturation of visual pathways and cortical areas.

Keywords: electrophysiology: clinical • visual development: infancy and childhood 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.