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Jin Zhang, Kevin Luzak, Kim Hyung, William G. Hodge; Disposable Nanostructure-laden Lens Sensor for Mornitoring Tear Glucose. Invest. Ophthalmol. Vis. Sci. 2011;52(14):453.
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The research work aims at developing a new disposable biosensor by applying the nanostructure-laden contact lens for the continuous, non-invasive monitoring of physiological glucose.
An nanostructured optical probe incorporated with hydrogel lens materials has been developed. The optical probe is consisted of the assembled transparent nanostructures which encapsulated the desired payload for conjugating the glucose in tear.
The advantageous of nanostructures lie in the special porous structures and large surface to volume ratio, which make sensor act as an analyte reservoir, and to have sensitive reaction with target, e.g. aqueous glucose. Here, 10 µl of aqueous glucose solutions were added on the surface of lens sensor. Meanwhile, signal processing algorithms have been used to obtain the pixels from the resulting matrix. It is found that the device is able to detect small amount of aqueous glucose in 0.01-10 mmol/L. Furthermore, the in-vitro cytotoxicity studies show the device is biocompatible.
This disposable biosensor to detect tear glucose may provide an alternative method to help patients manage the disease conveniently.
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