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Stanislao Rizzo, Federica Genovesi-Ebert, Nadine Hagedorn, Emanuele Di Bartolo, Federica Cresti, Michele Palla, Nadine Hagedorn; Coloring Of PFCL Facilitates Safe And Efficient Removal Of Temporary Tamponades. Invest. Ophthalmol. Vis. Sci. 2011;52(14):552.
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Aim of this study was to evaluate a new heavy liquid for ophthalmology. This new heavy liquid should effect a complete removal and a safer use due to a blue color. Due to the addition of small amounts of a dye, it is possible to see even the smallest residual droplets
A new heavy liquid which shows a blue color was tested on pig eyes. The heavy liquid consists of a PFCL (Perfluordecalin or Perfluoroctane) and a SFA (Semifluorinated Alkane). First clinical tests to evaluate the application and to prove the advantages of a colored heavy liquid were done. Laboratory experiments were performed to simulate a fluid-air exchange and a direct PFCL silicone oil exchange were done on fresh enucleated pig eyes. After removing the vitreous of the pig eye the retina was flattened with the colored heavy liquid. Fluid air exchange was performed. Direct fluid- silicone oil exchange was also performed on fresh enucleated pig eyes. Cytotoxicity was tested due to a standard ISO test using L929 cells. First clinical tests were also performed. The solution was also tested in the clinical practice on 10 patients that underwent pars plana vitrectomy for complicated retinal detachment
Test on pig eyes showed a good visibility of the solution during fluid-air exchange. After filling the eye with BSS a lot of small colored droplets were visible. It was easy to remove the small droplets. There was no staining of the retina, the vitreous or other tissues visible. Direct fluid silicone oil exchange was possible, but after a few minutes small amounts of the dye diffuses into the silicone oil phase and form a small corona around residual droplets. There were no signs for toxic effects on L929 cells. First tests on patient eyes showed a good visibility of the solution, a complete removal and no signs of toxicity or irritation. In the tested patients the Blue Heavy liquid was well tolerated, the visualization of PFCL under air was highlighted thus making the removal easier and allowing to avoid the inadvertent shift under the retina.No intraoperative or postoperative adverse events related to the blue liquid occurred.
A coloration of heavy liquids could be helpful for the complete removal of these substances. As known residual heavy liquids could result in side effects like emulsification of silicone oil and inflammation. A complete removal leads to a safer use of heavy liquids. A colored heavy liquid could be also used for training purposes of young ophthalmologists.
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