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Mohammad K. Ikram, Carol Y. Cheung, Wan T. Tay, Paul Mitchell, Jie J. Wang, Yingfeng Zheng, Raghavan Lavanya, N. Cheung, Tien Y. Wong; Retinal Vascular Caliber And Age-related Macular Degeneration - Singapore Indian Eye Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):82.
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To examine the relationship between retinal vascular caliber and prevalent age-related macular degeneration (AMD) in a population-based setting.
For the current analyses, we used data from the Singapore Indian Eye Study (SINDI), which is a population-based study among 3400 Indians aged 40 years and over aimed at determining the prevalence and risk factors for major eye diseases. We included a total of 3180 persons who had data available on retinal vascular calibre measurements and AMD status at baseline. Retinal images arteriolar and venular calibers were measured from digital photographs with computer-assisted software according to a standardized protocol. Images of the macular region were graded according to the modified Wisconsin age-related maculopathy grading system and classified as no, early or late AMD. Per participant the eye with the most advanced AMD stage was selected for the analyses. Logistic regression models were used to assess these associations adjusting for age and sex, and additionally for smoking, body mass index, blood pressure, total cholesterol and blood glucose levels.
Neither arteriolar nor venular calibers were related to prevalent AMD. For early AMD (n = 171), the age- and sex-adjusted odds ratio (OR) per standard deviation (SD) decrease in arteriolar caliber was 0.94 (95% confidence interval (CI): 0.81-1.10) and per SD increase in venular caliber was 1.01 (95% CI: 0.86-1.17)). The corresponding figures for late AMD (n = 11) were 1.32 (95% CI: 0.74-2.33) and 1.38 (95% CI: 0.79-2.42). After categorizing retinal vascular calibers into quartiles, there was no trend found. Additional adjustment did not alter these results.
Overall retinal vascular caliber were not related to AMD in this population-based study among Asian Indian participants. This contrasts with some previous studies in white populations.
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