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Janet S. Sunness, Robert W. Massof, Gary S. Rubin, Carol A. Applegate, Hilary Smolen; Quality Of Life Measures In Age-related Geographic Atrophy Of The Macula. Invest. Ophthalmol. Vis. Sci. 2011;52(14):91.
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To describe the difficulties experienced by patients with GAcross-sectionally and longitudinally.
A questionnaire was completed at baseline and annually by subjectsenrolled in the NIH-funded prospective natural history studyof geographic atrophy from AMD, conducted at Wilmer from 1992-2000.Each visit also included measurement of best-corrected visualacuity, contrast sensitivity, reading rate, low luminance visualacuity, and microperimetry, as well as a clinical examination.Measurement of GA area was performed using color fundus photographs.Results are shown for subjects with bilateral GA.
The tables give the percentage of subjects in each categoryreporting frequent difficulty.
Reading, recognizing faces, and finding a street sign worsenedwith worse visual acuity and with larger GA area at baseline.Longitudinally, reading and face recognition worsened significantlyover time. Difficulty with dim illumination was already presentin 81% of patients with good acuity, and did not worsen significantlywith worsening acuity or with larger GA. This information willbe helpful in designing quality of life questionnaires for futureGA clinical trials.
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