April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Prevalence Of Age-related Maculopathy In A Large Central European Population: Results From The Population-based GHS (Gutenberg Heart Study) - Eye Survey
Author Affiliations & Notes
  • Ulrike B. Kottler
    Ophthalmology,
    Johannes Gutenberg University Mainz, University Medical Center, Mainz, Germany
  • Christina Kramann
    Ophthalmology,
    Johannes Gutenberg University Mainz, University Medical Center, Mainz, Germany
  • René Hoehn
    Ophthalmology,
    Johannes Gutenberg University Mainz, University Medical Center, Mainz, Germany
  • Alireza Mirshahi
    Ophthalmology,
    Johannes Gutenberg University Mainz, University Medical Center, Mainz, Germany
  • Christian Wolfram
    Ophthalmology,
    Johannes Gutenberg University Mainz, University Medical Center, Mainz, Germany
  • Katrin Lorenz
    Ophthalmology,
    Johannes Gutenberg University Mainz, University Medical Center, Mainz, Germany
  • Isabella Zwiener
    Institute for Medical Biostatistics, Epidemiology and Informatics,
    Johannes Gutenberg University Mainz, University Medical Center, Mainz, Germany
  • Philipp S. Wild
    Department of Internal Medicine II,
    Johannes Gutenberg University Mainz, University Medical Center, Mainz, Germany
  • Stefan Blankenberg
    Department of Internal Medicine II,
    Johannes Gutenberg University Mainz, University Medical Center, Mainz, Germany
  • Norbert Pfeiffer
    Ophthalmology,
    Johannes Gutenberg University Mainz, University Medical Center, Mainz, Germany
  • Footnotes
    Commercial Relationships  Ulrike B. Kottler, None; Christina Kramann, None; René Hoehn, None; Alireza Mirshahi, None; Christian Wolfram, None; Katrin Lorenz, None; Isabella Zwiener, None; Philipp S. Wild, None; Stefan Blankenberg, None; Norbert Pfeiffer, None
  • Footnotes
    Support  The GHS is funded through the Stiftung Rheinland Pfalz für Innovation, contract no. AZ 961-386261/733, Boehringer Ingelheim, Philips MS and Novartis
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 93. doi:
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      Ulrike B. Kottler, Christina Kramann, René Hoehn, Alireza Mirshahi, Christian Wolfram, Katrin Lorenz, Isabella Zwiener, Philipp S. Wild, Stefan Blankenberg, Norbert Pfeiffer; Prevalence Of Age-related Maculopathy In A Large Central European Population: Results From The Population-based GHS (Gutenberg Heart Study) - Eye Survey. Invest. Ophthalmol. Vis. Sci. 2011;52(14):93.

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Abstract
 
Purpose:
 

To determine the prevalence of age-related maculopathy (ARM) in a large German sample.

 
Methods:
 

The GHS Eye Survey is a population-based, prospective, observational single-center study in the Rhein-Main-Region in western Mid-Germany with a total of nearly 15000 participants. The study sample is stratified for decades of age, gender and residence; age was 35 to 74 years at enrollment. Evaluation of fundus photographs of the first 5000 participants was performed by two experienced independent consultants in ophthalmology for the presence of hard and soft drusen, retinal pigmentary abnormalities, and late forms of atrophic or neovascular age-related macular generation (AMD).

 
Results:
 

Photographs of 4335 from 5000 participants were evaluable, 665 were not gradable due to reduced photo quality, obscuring lesions or missing pictures. Small hard drusen (<63 µm) were present in 37.4% of participants. Signs of early ARM (soft drusen, pigmentary abnormalities) were detected in 13.8%. Late AMD (geographic atrophy or neovascular AMD) was found in 0.1%, respectively.

 
Conclusions:
 

The GHS Eye Survey is the first population-based study on the prevalence of age-related maculopathy in a representative German sample. Small hard drusen are frequent, advanced AMD is rare in this population. These findings are comparable to other European populations, in particular the Rotterdam Eye Study. The randomly selected sample will provide substantial epidemiologic data including incidence data after recall.

 
Keywords: clinical (human) or epidemiologic studies: prevalence/incidence • age-related macular degeneration • macula/fovea 
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