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Jean-Claude Quintyn, Sylvie Caspar-Bauguil, Brigitte Périquet, Anne Galinier; Status Of Oxidative Stress On Patients With Active Form Of Age Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2011;52(14):99.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the state of stress oxidation on age macular degeneration patients using a biological test named "KRL".
This prospective study is on age macular degeneration patients with activ neovascular or atrophic form. No one had vitamin supplementation. The KRL test evaluates the resistance generated under standardized conditions to lyses of red blood cells treated by free radicals. We used the KRL test to evaluate the global oxidation stress on 23 patients with neovascular form, 6 patients with activ atrophic form and on 22 control patients. Results are expressed as the time that is required to reach 50% of maximal haemolysis (half-haemolysis time, in minutes), the lower the results, the lower antioxidant capacity.
The three groups are similar for age, sex; BMI, smoking status. The mean of red cell half time is 84,0 (SD:6.5) min for the control group and 78.5 (SD:6.2) min for the patients group with neovascular form, and 79.6 (SD:5.5) for the patients group with active atrophic form. A significant haemolysis is noticed between the control group and the patients group (p<0.001).
AREDS study reported the benefit action of antioxidants against age macular degeneration. The protective mechanisms against oxidative RPE damage decrease dramatically in age macular degeneration patients. We demonstrated age macular degeneration patients have a diminution of overall antioxidant defence too. KRL test is an easy test which might use to determine the predisposed patients.The age macular degeneration patients have an increased oxidative stress. Age macular degeneration may be not only a local disease but a systemic disease too.
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