March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Repeatability Of Retinal Macular Thickness Measurements In Healthy Subjects And Diabetic Patients With Clinically Significant Macular Edema: Evaluation Of The Follow-up System Of Spectralis Optical Coherence Tomography
Marco Lupidi; Tito Fiore; Barbara Iaccheri; Anna Caricato; Alessio Cerquaglia; Daniela Fruttini; Silvia Manes; Marsela Menkulazi; Carlo Cagini
Author Affiliations & Notes
  • Marco Lupidi
    Ophthalmology, Eye Clinic, University of Perugia, Perugia, Italy
  • Tito Fiore
    Ophthalmology, Eye Clinic, University of Perugia, Perugia, Italy
  • Barbara Iaccheri
    Ophthalmology, Eye Clinic, University of Perugia, Perugia, Italy
  • Anna Caricato
    Ophthalmology, Eye Clinic, University of Perugia, Perugia, Italy
  • Alessio Cerquaglia
    Ophthalmology, Eye Clinic, University of Perugia, Perugia, Italy
  • Daniela Fruttini
    Economic, Financial and Statistical, University of Perugia, Perugia, Italy
  • Silvia Manes
    Ophthalmology, Eye Clinic, University of Perugia, Perugia, Italy
  • Marsela Menkulazi
    Ophthalmology, Eye Clinic, University of Perugia, Perugia, Italy
  • Carlo Cagini
    Ophthalmology, Eye Clinic, University of Perugia, Perugia, Italy
  • Footnotes
    Commercial Relationships  Marco Lupidi, None; Tito Fiore, None; Barbara Iaccheri, None; Anna Caricato, None; Alessio Cerquaglia, None; Daniela Fruttini, None; Silvia Manes, None; Marsela Menkulazi, None; Carlo Cagini, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 817. doi:
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      Marco Lupidi, Tito Fiore, Barbara Iaccheri, Anna Caricato, Alessio Cerquaglia, Daniela Fruttini, Silvia Manes, Marsela Menkulazi, Carlo Cagini; Repeatability Of Retinal Macular Thickness Measurements In Healthy Subjects And Diabetic Patients With Clinically Significant Macular Edema: Evaluation Of The Follow-up System Of Spectralis Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2012;53(14):817.

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Abstract

Purpose: : To compare the repeatability of OCT Spectralis retinal thickness (RT) measurements in healthy subjects and diabetic patients with clinical significant macular edema (CSME) with or without the use of the follow-up system.

Methods: : Fourteen eyes of 14 healthy subjects and twenty eyes of 20 diabetic patients with CSME were included in the study. Repeatability and intrasession correlation coefficients were tested with 20 x 15 degree raster scans consisting of 19 high-resolution line scans (15 frames per scan) that were repeated three times by 1 experienced examiner. The first scan was set as the reference scan, the second and third scan were the follow-up scans and were respectively performed with and without the use of the follow-up mode.

Results: : The means and standard deviations for the central foveal subfield (CSF) in healthy subjects and diabetic patients were respectively 298 ± 25 μm and 393 ± 113 μm. The absolute change in RT with and without the use of the follow-up mode was respectively in healthy subjects 0.29 ± 2.23 μm and 3.29 ± 12 μm, and in diabetic patients with CSME 1.05 ± 3.82 μm and 5.8 ± 23.29 μm. Particularly in diabetic patients, examining the CSF, coefficient of repeatability was respectively less and more than 2% with and without using the follow-up mode, and difference between obtained measurement was statistically significant (p<0.05) when comparing data acquired with and without follow-up mode.

Conclusions: : These preliminary results support the hypothesis that the follow-up system improves the repeatability either in healthy subjects, or in diabetic patients. The wider improvement of the repeatability observed in diabetic patients compared to healthy subjects when using the follow-up system could be related to the poor patient fixation or eye movement in patients with CSME.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • edema • diabetes 
© 2012, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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