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Marco Lupidi, Tito Fiore, Barbara Iaccheri, Anna Caricato, Alessio Cerquaglia, Daniela Fruttini, Silvia Manes, Marsela Menkulazi, Carlo Cagini; Repeatability Of Retinal Macular Thickness Measurements In Healthy Subjects And Diabetic Patients With Clinically Significant Macular Edema: Evaluation Of The Follow-up System Of Spectralis Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2012;53(14):817.
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To compare the repeatability of OCT Spectralis retinal thickness (RT) measurements in healthy subjects and diabetic patients with clinical significant macular edema (CSME) with or without the use of the follow-up system.
Fourteen eyes of 14 healthy subjects and twenty eyes of 20 diabetic patients with CSME were included in the study. Repeatability and intrasession correlation coefficients were tested with 20 x 15 degree raster scans consisting of 19 high-resolution line scans (15 frames per scan) that were repeated three times by 1 experienced examiner. The first scan was set as the reference scan, the second and third scan were the follow-up scans and were respectively performed with and without the use of the follow-up mode.
The means and standard deviations for the central foveal subfield (CSF) in healthy subjects and diabetic patients were respectively 298 ± 25 μm and 393 ± 113 μm. The absolute change in RT with and without the use of the follow-up mode was respectively in healthy subjects 0.29 ± 2.23 μm and 3.29 ± 12 μm, and in diabetic patients with CSME 1.05 ± 3.82 μm and 5.8 ± 23.29 μm. Particularly in diabetic patients, examining the CSF, coefficient of repeatability was respectively less and more than 2% with and without using the follow-up mode, and difference between obtained measurement was statistically significant (p<0.05) when comparing data acquired with and without follow-up mode.
These preliminary results support the hypothesis that the follow-up system improves the repeatability either in healthy subjects, or in diabetic patients. The wider improvement of the repeatability observed in diabetic patients compared to healthy subjects when using the follow-up system could be related to the poor patient fixation or eye movement in patients with CSME.
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