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Michaella Goldstein, Zohar Habot-Wilner, Anat Loewenstein, Dafna Goldenberg; High Resolution Optical Coherence Tomography Retinal and Choroidal Findings in Ocular Toxoplasmosis. Invest. Ophthalmol. Vis. Sci. 2012;53(14):819. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To demonstrate the different retinal and choroidal morphological characteristics on SD Optical Coherence Tomography (OCT) in ocular toxoplasmosis.
Case series of patients presented with ocular toxoplasmosis from August 2009 were included in the study. All patients underwent a detailed ophthalmic examination, fundus color photography and Spectralis SD-OCT imaging at presentation and during follow-up. OCT scans were directed to the pathological retinal and choroidal areas that were demonstrated in the clinical examination.
Sixteen eyes (13 patients) were included. Eleven active lesions were demonstrated in 9 eyes (8 patients) and 25 chorioretinal scars were demonstrated in 12 eyes (10 patients). The active lesion demonstrated retinal thickening, disruption and hyper-reflectivity of the retinal layers. During follow-up the retina became thinner and a scar formation was noted. Hyper-reflective deposits were noted on the posterior hyaloid, within the vitreo-retinal interface and in the inner retina layres. Those deposits fade with time. Vitritis could be demonstrated as multiple hyper-reflective dots in the vitreous cavity during the active phase, which resolved during follow-up. Choroidal findings included significant thickening returning to normal thickness when scars were formed.OCT findings of the chorioretinal scars demonstrated sharply demarcated borders, thinning of neurosensory retina, ELM & IS/OS junction interruption, disorganization of the retinal layers and RPE changes. The choriocapillaries demonstrated a specific pattern with a significant hypereflectivity. In addition, the posterior hyaloid was thickened and partially detached over the toxoplasma scar. The OCT retinal and choroidal features remained unchanged during the follow up.
SD-OCT is a useful tool in the diagnosis and follow-up of patients with ocular toxoplasmosis and provides a better understanding of the pathogenesis of the disease.
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