March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Pericentral Ganglion Cell Layer Thickness Decreases with Age in Normal Eyes as Measured by Spectral-Domain Optical Coherence Tomography
Author Affiliations & Notes
  • Nazli Demirkaya
    Ophthalmology,
    Academic Medical Center, Amsterdam, The Netherlands
  • Hille W. van Dijk
    Ophthalmology,
    Academic Medical Center, Amsterdam, The Netherlands
  • Reinier O. Schlingemann
    Ophthalmology,
    Academic Medical Center, Amsterdam, The Netherlands
  • Michael D. Abramoff
    Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa
    Ophthalmology and Visual Sciences, The University of Iowa Hospital and Clinics, Iowa, Iowa
  • Mona K. Garvin
    Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa
  • Milan Sonka
    Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa
    Ophthalmology and Visual Sciences, The University of Iowa Hospital and Clinics, Iowa, Iowa
  • Frank D. Verbraak
    Ophthalmology,
    Biomedical Engineering and Physics,
    Academic Medical Center, Amsterdam, The Netherlands
  • Footnotes
    Commercial Relationships  Nazli Demirkaya, None; Hille W. van Dijk, None; Reinier O. Schlingemann, None; Michael D. Abramoff, University of Iowa (P); Mona K. Garvin, None; Milan Sonka, None; Frank D. Verbraak, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 823. doi:https://doi.org/
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      Nazli Demirkaya, Hille W. van Dijk, Reinier O. Schlingemann, Michael D. Abramoff, Mona K. Garvin, Milan Sonka, Frank D. Verbraak; Pericentral Ganglion Cell Layer Thickness Decreases with Age in Normal Eyes as Measured by Spectral-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2012;53(14):823. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the effect of age on individual retinal layer thicknesses in healthy subjects measured by Spectral-Domain Optical Coherence Tomography.

Methods: : Eighty-four healthy subjects with an age ranging between 18 and 70 years were examined with Spectral-Domain Optical Coherence Tomography (SD-OCT, Topcon, Marck II). Mean layer thickness was calculated for 7 retinal layers, in the central area (region 1 of the 9 ETDRS regions), in the pericentral area (ETDRS regions 2 to 5), and the peripheral area (ETDRS region 6 to 9) following automated segmentation using a custom made algorithm, which uses a fully three-dimensional graph search approach. To avoid the influence of confounders like gender and axial length we calculated for each layer in each area the ratio Mean Layer Thickness/ Total Retinal Thickness (Mean LT/Mean Total RT). The Pearson correlation test was performed for each retinal layer to determine the relationship between age and the ratio Mean LT/Mean Total RT.

Results: : There was a significant negative correlation between the Mean LT/Mean Total RT ratio of the pericentral ganglion cell layer and age (R=-0,300, P=0,006). All other pericentral layer ratios and all layer ratios in the central and peripheral areas did not show significant change in thickness with age.

Conclusions: : This study demonstrates in healthy individuals a thinning of the ganglion cell layer in the pericentral area with increasing age.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina • imaging/image analysis: clinical 
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