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Fabiana F. Goncalves, Luiz Filipe A. Lucatto, Andre S. Camargo, Eric P. Andrade, Luiz Alberto S. Melo, Jr., Denis B. Bichuetti, Enedina Maria L. Oliveira, Ivan M. Tavares; Retinal Never Fiber Layer Thickness And Patients With Multiple Sclerosis: Correlation With The Expanded Disability Status Scale And Evaluation In Patients Without Optic Neuritis. Invest. Ophthalmol. Vis. Sci. 2012;53(14):825.
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To correlate the retinal nerve fiber layer (RNFL) thickness with expanded disability status scale (EDSS), that is a method of quantifying disability in multiple sclerosis (MS) and also to demonstrate whether the RNFL is abnormal in patients with MS without history of optic neuritis.
In this cross-sectional study, patients with MS diagnosed according to clinical and neuroimaging criteria were recruited. Eyes with a recent clinical diagnosis of optic neuritis (less than six months), glaucoma, optic neuropathy (other than MS and NMO-related optic neuritis), or other relevant retinal and/or optic nerve disease were excluded. The eyes had the parapapillary RNFL thickness measured by SD-OCT, using the Spectralis (software version 4.0, Heidelberg Engineering, Dossenheim, Germany), and by SLP, using the GDxVCC (software version 5.3.3, Carl Zeiss Meditec Inc., Dublin, CA). The ophthalmologist was blind about the values of the EDSS and about previous history of optic neuritis.
Ninety-two eyes of 46 patients with MS. The mean value of the EDSS was 2.2, with the standard deviation (SD) of 1.2, the mean RNFL average thickness by the OCT was 88.0 µm (14.5 SD) and by the SLP was 53.5 (8.2 SD) µm. The correlation is seen in the table 1. From 42 eyes of 21 patients with MS without optic neuritis in both eyes, 7 eyes (18%) were classified as outside normal limits by OCT and 2 eyes (5%) had the GDX NFI index greater than 50. The percentage of abnormal results is shown in Table 2.
There is a negative, low to moderate correlation between EDSS and RNFL thickness. Even in patients without history of optic neuritis the RNFL can be affected in patients with MS, confirming the degenerating character of the disease.
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