Abstract
Purpose: :
To investigate a relationship between the inner segment-outer segment (IS-OS) layer integrity and overlying retinal sensitivity assessed by microperimetry (MP) in patients with diabetic retinopathy (DR).
Methods: :
Point-to-point analysis of correlation between MP retinal sensitivities and corresponding status of the underlying IS-OS layer was performed in 55 eyes (43 patients) with DR.
Results: :
Retinal sensitivity was moderately correlated with the integrity of IS-OS layer (r= -0.41). The correlation was worse when intraretinal cystic changes were present in the locus of measured retinal sensitivity.
Conclusions: :
Loss of IS-OS layer was moderately correlated with poor retinal sensitivity in the eyes of patients with diabetic retinopathy. The presence of overlying intraretinal cysts was found to have an additional impact on retinal sensitivity as well as the loss of integrity of IS-OS layer in diabetic retinopathy.
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • diabetic retinopathy • photoreceptors