March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Are Classic Pre-epithelial Choroidal New Vessels (prpe-cnv) Only Part Of Armd?
Author Affiliations & Notes
  • Gisele s. Soubrane
    Ophthalmology, HOTEL DIEU, PARIS, France
  • Francine Behar Cohen
    Ophthalmology, University ParisV, Paris, France
  • Rocio Blanco Garavito
    Ophthalmology, Creteil Eye Clinic Univ Hospital, Creteil, France
  • AMEP study group
    Ophthalmology, HOTEL DIEU, PARIS, France
  • Footnotes
    Commercial Relationships  Gisele S. Soubrane, None; Francine Behar Cohen, None; Rocio Blanco Garavito, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 854. doi:
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      Gisele s. Soubrane, Francine Behar Cohen, Rocio Blanco Garavito, AMEP study group; Are Classic Pre-epithelial Choroidal New Vessels (prpe-cnv) Only Part Of Armd?. Invest. Ophthalmol. Vis. Sci. 2012;53(14):854.

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      © ARVO (1962-2015); The Authors (2016-present)

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To assess the clinical features and response to therapy of angiographically defined PRPE- CNV in patients presenting the accepted characteristics of ARMD


In this still on-going retrospective study, all second eyes presenting with PRPE-CNV were included if the patient was more than 60 years of age. A complete ophthalmologic examination had to be available, including pre-injection frames, fluorescein angiography, ICG angiography and SD-OCT in order to identify all types of drusen and to exclude occult sub-epithelial CNV. A 6 and 12 month post anti-VEGF treatment examination allowed evaluation of response to treatment.


The analysis of the first 100 eyes showed that initially PRPE-CNV were accompanied by hard drusen in 19 eyes but no high risk lesions neither on fluorescein nor on ICG angiography could be ascertained. The response to anti-VEGF injections was in all cases rapid (after 2 to 4 injections) and resulted in quiescent CNV on the angiographic examinations and a complete resorbtion of intra-retinal fluid on OCT.


This study raises a doubt on the belonging of PRPE-CNV to ARMD as these rare clinical form present specific features and responds unusually favourably to anti-VEGF treatment. In addition, a precise genetic background (ARSM2-HTRA1) has been previously identified. These different characteristics suggest that classic PRPE-CNV is a group apart from ARMD, possibly idiopathic CNV in elderly patients.

Keywords: imaging/image analysis: clinical • choroid: neovascularization • clinical (human) or epidemiologic studies: natural history 

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