March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Changes in Retinal Nerve Fiber Layer in Eyes Treated with AntiVEGF Intraocular Injections for Neovascular AMD
Author Affiliations & Notes
  • Pamela A. Weber
    Island Retina, Shirley, New York
  • Tugce Karalar
    Island Retina, Shirley, New York
  • James Soque
    Island Retina, Shirley, New York
  • Footnotes
    Commercial Relationships  Pamela A. Weber, None; Tugce Karalar, None; James Soque, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 877. doi:
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      Pamela A. Weber, Tugce Karalar, James Soque; Changes in Retinal Nerve Fiber Layer in Eyes Treated with AntiVEGF Intraocular Injections for Neovascular AMD. Invest. Ophthalmol. Vis. Sci. 2012;53(14):877.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : to evaluate loss of the RNFL in eyes receiving multiple intraocular injections of anti-VEGF medications for the treatment of neovascular age-related macular degeneration (NVAMD).

Methods: : eyes with NVAMD that had a Stratus RNFL analysis followed by a 2nd study at least 48 months later were included.The eye had to have a signal stregth of 4 or better on OCT, a minimum of 5 injections of an antiVEGF drug, and no history of glaucoma. Untreated fellow eyes were used as controls.

Results: : We identified 29 eyes of 22 patients. There were 12 untreated fellow eyes that were analyzed as controls.Eyes received from 5-40 injections:mean and median 19 and 18. There was no change in the RNFL when comparing the treated to the controls (p=0.663). More intense treatment was not associated with decreases in RNFL.The baseline and follow-up average RNFL for treated eyes were 88.24(+11.1) and 83.66(+9.52)(p=0.101). and for controls were 88.92(+12.87) and 85.00(+10.05)(p=0.11).

Conclusions: : there was no statistically significant change in the RNFL assocated with intraocular antiVEGF drugs for the treatment of NVAMD in eyes followed for at least 4 years.

Keywords: age-related macular degeneration • imaging/image analysis: clinical • vascular endothelial growth factor 

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