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Tae Kwann Park, Chan Hee Moon, Young-Hoon Ohn; Visual Prognostic Value of the Photopic Negative Response and Optical Coherence Tomography in Retinal Vein Occlusion Following Intravitreal Bevacizumab Injection. Invest. Ophthalmol. Vis. Sci. 2012;53(14):974.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the potential of the photopic negative response (PhNR) and optical coherence tomography (OCT) for predicting visual outcomes in retinal vein occlusion (RVO) with macular edema following intravitreal injection of bevacizumab, prospectively.
A total of thirty-six eyes of 36 consecutive patients with macular edema due to unilateral central retinal vein occlusion in 19 patients, and branch retinal vein occlusion in 17 patients were studied before and 4 weeks after intravitreal injection of bevacizumab with complete ophthalmic examination, PhNR and OCT. Pre-treatment measurements of affected eyes were compared with that of unaffected fellow eyes and post-treatment measurements of affected eyes with paired samples T-test. Pearson’s correlation and linear regression analyses were conducted to assess the relationship between PhNR, central subfield thickness (CST) measured by OCT before treatment and Log MAR visual acuity (VA) after treatment.
VA, PhNR and CST were worse significantly in affected eyes compared to unaffected eyes. VA was improved significantly from 0.72±0.48 before treatment to 0.35±0.33 after treatment. CST was reduced significantly from 626.70±197.88μm before treatment to 315.23±115.73μm after treatment. PhNR parameters did not show any changes in amplitude and implicit time following intravitreal injection of bevacizumab. Pre-treatment measurements of PhNR amplitude (R=-0.406, R2=0.165, P=0.029) and implicit time (R=0.416, R2=0.173, P=0.025) were correlated significantly with post-treatment VA. The implicit time showed a stronger correlation than the amplitude. Pre-treatment CST (R=0.461, R2=0.213, P=0.006) was also correlated significantly with post-treatment VA.
An eye with the better amplitude and implicit time of PhNR and CST were associated with the better visual outcome after intravitreal injection of bevacizumab. PhNR and OCT could be a useful prognostic indicator in the pre-treatment evaluation of RVO with macular edema.
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