March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Agreement Between Time Domain And Spectral Domain OCT In Assessment Of Macular Thickness In Patients With Macular Telangiectasia Type 2
Raeba Mathew; Irene Leung; Ferenc Sallo; Alan C. Bird; Tunde Peto; MacTel Study Group
Author Affiliations & Notes
  • Raeba Mathew
    Ophthalmology, NIHR Biomedical Research Centre for Ophthalmology,Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • Irene Leung
    Ophthalmology, NIHR Biomedical Research Centre for Ophthalmology,Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • Ferenc Sallo
    Ophthalmology, NIHR Biomedical Research Centre for Ophthalmology,Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • Alan C. Bird
    Ophthalmology, NIHR Biomedical Research Centre for Ophthalmology,Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • Tunde Peto
    Ophthalmology, NIHR Biomedical Research Centre for Ophthalmology,Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • MacTel Study Group
    Ophthalmology, NIHR Biomedical Research Centre for Ophthalmology,Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • Footnotes
    Commercial Relationships  Raeba Mathew, None; Irene Leung, None; Ferenc Sallo, None; Alan C. Bird, None; Tunde Peto, None
  • Footnotes
    Support  Lowy Medical Foundation
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 981. doi:
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      Raeba Mathew, Irene Leung, Ferenc Sallo, Alan C. Bird, Tunde Peto, MacTel Study Group; Agreement Between Time Domain And Spectral Domain OCT In Assessment Of Macular Thickness In Patients With Macular Telangiectasia Type 2. Invest. Ophthalmol. Vis. Sci. 2012;53(14):981.

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Abstract

Purpose: : A large cohort of patients with Type 2 Macular Telangiectasia (MacTel) has been followed since 2005, initially using the then available Time domain (TD) optical coherence tomography (OCT) that was later superseded by Spectral domain (SD) OCT. The aim of this study was to assess the effect of change of instrumentation on the estimates of retinal thickness in MacTel.

Methods: : At the time of retiring the TD-OCT (Stratus, Carl Zeiss Meditech Inc) both TD-OCT and SD-OCT {Spectralis, Heidelberg engineering, Germany,( 146 eyes) or Cirrus Carl Zeiss Meditech Inc (222 eyes)}, macular scans were performed on patients with MacTel at the same visit. The macular thickness in the nine subfields of the ETDRS grid and the macular volume was obtained and analysed at the Moorfields Eye Hospital Reading Centre. Bland Altman plots were created to assess agreement in the measurements between the machines.

Results: : The macular thicknesses in all nine subfields and the macular volume were significantly higher (p<0.001) when measured by SD OCT. The SD OCT measurements by the Spectralis showed a higher mean value of approximately 62 microns and the Cirrus OCT 41 microns, when compared to the TD Stratus OCT. The Bland Altman plots showed that the TD and SD OCT machines could not be used interchangeably, but the conversion could be possible by adding the above values of 62 and 41 microns to the TD OCT measurements for Spectralis and Cirrus machines respectively.

Conclusions: : The estimates of conversion of macular thickness from TD to SD OCT are not significantly different from those found in normal population or other pathological conditions like diabetic macular oedema or age related macular degeneration and can thus be used for longitudinal follow up of the cohort of MacTel patients.

Keywords: macular pigment • clinical (human) or epidemiologic studies: prevalence/incidence • retina 
© 2012, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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