March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Are Optic Disc Sterometric Parameters Associated with Retinal Vein Occlusion?
Author Affiliations & Notes
  • Errol W. Chan
    Ophthalmology, National University Health System, Singapore, Singapore
  • Tien Y. Wong
    Singapore Eye Research Institute,
    National University of Singapore, Singapore, Singapore
  • Yingfeng Zheng
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
  • Seng Chee Loon
    Ophthalmology, National University Hospital, Singapore, Singapore
  • Carol Y. Cheung
    Level 5, SNEC Building, Singapore Eye Research Institute, Singapore, Singapore
  • Seang-Mei Saw
    Epidemiology and Public Health, National Univ of Singapore, Singapore, Singapore
  • Tin Aung
    Glaucoma, Singapore National Eye Center, Singapore, Singapore
  • Ching-Yu Cheng
    Department of Ophthalmology,
    National University of Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships  Errol W. Chan, None; Tien Y. Wong, None; Yingfeng Zheng, None; Seng Chee Loon, None; Carol Y. Cheung, None; Seang-Mei Saw, None; Tin Aung, None; Ching-Yu Cheng, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1002. doi:
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      Errol W. Chan, Tien Y. Wong, Yingfeng Zheng, Seng Chee Loon, Carol Y. Cheung, Seang-Mei Saw, Tin Aung, Ching-Yu Cheng; Are Optic Disc Sterometric Parameters Associated with Retinal Vein Occlusion?. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1002.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : Previous clinic-based studies suggest that smaller optic disc size may be associated with the risk of retinal vein occlusion (RVO). We aimed to validate the association between RVO and optic disc stereometric parameters measured with the Heidelberg Retinal Tomograph-2 (HRT-2) in a population-based study.

Methods: : Subjects with RVO were identified from the Singapore Indian Eye Study (SINDI), a population-based study of 3,400 Singaporean Indians aged 40 years or older. There were a total of 6,177 eyes (23 RVO and 6,154 non-RVO) with retinal photographs and HRT-2 data available. HRT-2 stereometric parameters (disc area, cup area, rim area, cup-to-disc area ratio, cup volume, rim volume, mean cup depth, cup shape measure, horizontal and vertical cup-disc ratio) were quantified and compared between eyes with RVO and without RVO. Generalized estimating equation method was used to account for the correlation between fellow eyes in the regression analysis.

Results: : The optic disc area was 2.16 ± 0.38 mm2 in RVO eyes and 1.97 ± 0.44 mm2 in non-RVO eyes. Larger optic disc area (≥1.92 mm2) was associated with higher risk of RVO (odds ratio = 3.22, 95% Confidence interval [CI]: 1.14, 9.01, P = 0.027), compared with smaller disc area (<1.92mm2), after adjustments for age, sex, spherical equivalent, intraocular pressure, hypertension, lipids, diabetes, and history of angina, heart attack, and stroke. The cup area was 0.82 ± 0.33 mm2 in RVO eyes and 0.63 ± 0.41 mm2 in non-RVO eyes. Larger cup area (≥ 0.57 mm2) was more likely to have RVO (OR = 2.28, 95% CI: 1.02, 5.10, P = 0.044), compared with smaller cup area (<0.57 mm2), after similar adjustments. Other optic disc stereometric parameters were not significantly associated with RVO.

Conclusions: : Optic disc and cup areas are larger in eyes with RVO in the SINDI population. Further investigation is needed to clarify the role of optic disc stereometric parameters in other populations.

Keywords: retina • optic disc • clinical (human) or epidemiologic studies: risk factor assessment 

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