March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Characterization of Choroidal Structure in Sympathetic Ophthalmia using Optical Coherence Tomography
Author Affiliations & Notes
  • Vikas Tah
    Research and development,
    Moorfields Eye Hospital, London, United Kingdom
  • Javier Zarranz-Ventura
    Medical Retina, Department of Ophthalmology, Clínica Universidad de Navarra,, Navarra, Spain
  • Dawn A. Sim
    Medical Retina,
    Moorfields Eye Hospital, London, United Kingdom
  • Pearse A. Keane
    NIHR Biomed Resrch Ctr for Opht, Moorfields Eye Hosp NHS Fndtn Trust, London, United Kingdom
  • Catherine A. Egan
    Medical Retina,
    Moorfields Eye Hospital, London, United Kingdom
  • Praveen J. Patel
    Research & Development,
    Moorfields Eye Hospital, London, United Kingdom
  • Richard W. Lee
    School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
  • Adnan Tufail
    Ophthalmology,
    Moorfields Eye Hospital, London, United Kingdom
  • Carlos E. Pavesio
    Medical Retina Service,
    Moorfields Eye Hospital, London, United Kingdom
  • Mark C. Westcott
    Dept of Ophthalmology, St Bartholomew's Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships  Vikas Tah, None; Javier Zarranz-Ventura, None; Dawn A. Sim, None; Pearse A. Keane, None; Catherine A. Egan, None; Praveen J. Patel, None; Richard W. Lee, None; Adnan Tufail, None; Carlos E. Pavesio, None; Mark C. Westcott, None
  • Footnotes
    Support  NIHR
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1156. doi:https://doi.org/
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      Vikas Tah, Javier Zarranz-Ventura, Dawn A. Sim, Pearse A. Keane, Catherine A. Egan, Praveen J. Patel, Richard W. Lee, Adnan Tufail, Carlos E. Pavesio, Mark C. Westcott; Characterization of Choroidal Structure in Sympathetic Ophthalmia using Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1156. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

Characterization of choroidal structure in sympathetic ophthalmia using optical coherence tomography

 
Methods:
 

Images were retrospectively collected from patients with known sympathetic granulomatous panuveitis. Data regarding disease activity of the sympathizing eye, treatment, and type of injury to the exciting eye was obtained from electronic patient records.

 
Results:
 

Five eyes from five patients were included in the analysis. The male to female ratio was 3:2. There were 3 Caucasian and 2 African patients. Mean age was 49.6 years (Range 21-72). 4 patients had previous ennucleations, and 1 had a phthsical eye. All patients suffered from traumatic penetrating injuries. Time from injury to the exciting eye ranged from 8 years to 56 years. 2 patients had active disease, 3 were quiescent. Four patients were on oral steroids at the time of image acquisition. Generalized choroidal atrophic changes on EDI OCT were observed in all cases. There was a loss of choroidal vascularity as compared to normal controls, with increased diffuse interstitial signal between choroidal vessels in Haller’s large vessel layer observed in both active and quiescent disease states.

 
Conclusions:
 

Histological features of sympathetic ophthalmia classically describe a thickened posterior choroid secondary to inflammatory infiltration. We have conversely observed a thinned atrophic choroid in these patients, irrespective of disease activity. Increased signal within the choroidal vessels may represent scarring or inflammatory cellular infiltrate.  

 

 
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • uvea • choroid 
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