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Yogita Kashyap, Chavakij Bhoomibunchoo, Gennady Landa, Nicole Scripsema, Thomas O. Muldoon, Richard Rosen; Clinical Monitoring of Retinal Blood Flow Response to Pan Retinal Photocoagulation(PRP) Using the Retinal Functional Imager (RFI). Invest. Ophthalmol. Vis. Sci. 2012;53(14):1162.
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To evaluate retinal blood flow using the RFI to monitor PRP response.
The RFI captures blood flow sequences that mirror clinical changes. RFI imaging was performed pre and post PRP.
Mean venous velocities before and after PRP treatment were 2.82 +/- 0.61 mm/sec and 2.62 +/- 0.37 mm/sec after PRP, suggesting a significant decrease of at least 14.04% (p =0.03). Mean arterial velocities before PRP treatment were 4.48 +/- 1.42 mm/sec and 4.46 +/- 1.57 mm/sec after PRP which was not significant.
The RFI may prove useful in the clinical management of diabetic patients undergoing laser therapy. Reduced venous velocity could serve as a non-invasive surrogate endpoint of laser effectiveness for suppression of PDR activity.
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