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Ulrich Kellner, Simone Kellner, Silke Weinitz, Gazaleh Farmand; Spectral Domain OCT Inner Retinal Disconfiguration Associated With Retinal Dysfunction. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1172.
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© ARVO (1962-2015); The Authors (2016-present)
To report a novel Spectral-domain OCT (SD-OCT) feature of inner retinal alterations associated with retinal dysfunction.
Two female patients (age 43 and 47 y.) were examined clinically and with near-infrared reflectance (NIR), red-free imaging (RF), fundus autofluorescence (FAF), near-infrared autofluorescence (NIA), fluorescein angiography (FAG) and SD-OCT (Spectralis HRA & OCT, Heidelberg Engineering, Germany) and multifocal electroretinography (mfERG) according to ISCEV standard.
Both females were referred with recent visual loss on both eyes. Visual acuity was 0.3-0.5. On ophthalmoscopy the fundus appeared normal. Retinal imaging with NIR, RF, FAF, NIA and FAG did not reveal retinal, retinal pigment epithelial or choroidal abnormalities. The SD-OCT showed a normal retinal thickness at the posterior pole. The retinal pigment epithelial layer, outer retinal layer and external limiting membrane line as well as the outer part of the outer nuclear layer were normal. The inner part of the outer nuclear layer bordering to the outer plexiform layer, the outer plexiform layer and the inner nuclear layer showed worl-like irregularities. The inner plexiform layer, ganglion cell layer and nerve fiber layer appeared normal again. MfERG showed reduced amplitudes at the posterior pole. The SD-OCT alterations appeared unchanged over 3 months.
Retinal dysfunction may be associated with alterations of the inner retinal layers that can only be detected with SD-OCT. The origin of the novel SD-OCT phenomenon presented here remains unclear, long-term follow-up will be necessary to define the course of disease and possible associated factors.
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