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Darby D. Miller, Benjamin Nicholson, Monica Dalal, Wendy Smith, Naima Jacobs-El, H. Nida Sen; Ultra-wide-field Angiography Improves Detection Of Uveitic Retinal Vascular Retinopathy. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1189.
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To evaluate patients with different forms of uveitis using ultra-wide-field fluorescein angiography and to compare visualized retinal pathology with that seen on conventional 9 standard field fluorescein angiography imaging.
Retrospective case series of thirty-six eyes from twenty-one patients with known uveitic diagnoses who underwent diagnostic fluorescein angiography using the Optos Optomap Panoramic imaging (Optos PLC, Scotland) and conventional 9 standard field imaging. The visualized area of the retina and associated retinal vasculature were evaluated and compared with the derived 9 standard field angiography images.
Ultra-wide-field fluorescein angiography demonstrated more retinal surface when compared with conventional 9 standard field fluorescein angiography imaging. Compared with conventional 9 standard field angiography, ultra-wide-field fluorescein angiography showed more retinal vascular leakage in fourteen eyes (39%) from thirteen different patients. Of these thirteen patients, management changes were implemented in two patients. Due to the progression of the posterior uveitic syndromes, as seen on the ultra-wide-field imaging, new immunomodulatory therapies were added to the treatment regimens of both patients. Anatomic locations included intermediate (17%), posterior (44%), and panuveitis (39%). Common diagnoses included idiopathic uveitis (28%, most common), sarcoid-related uveitis (17%), and Vogt-Koyanagi-Harada syndrome (11%).
Ultra-wide-field fluorescein angiography, compared with conventional 9 standard field fluorescein angiography imaging, reveals more retinal vascular leakage in patients with intermediate, posterior or panuveitis. Improved retinal visualization using Optos may consequently influence the clinical management of patients and alter the course of disease.
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