Abstract
Purpose: :
To compare the significance of serum angiotensin converting enzyme and lysozyme levels between the patients with active ocular involvement of sarcoidosis and Behcet disease.
Methods: :
24 patients with active ocular involvement of sarcoidosis and 24 patients with ocular manifestations of Behcet disease were included in this study according to the tenets of Declaration of Helsinki. The diagnostic criteria were based on ocular signs, laboratory investigations and biopsy results. Serum levels of angiotensin converting enzyme and lysozyme were studied by the enzme-linked immunosorbent assay. SPSS 15.0 software for 2 sample t-test and Mann Whitney U test was used for the statistical evaluation.
Results: :
The mean(standard deviation,SD) of serum level of angiotensin converting enzyme for patients with Behcet disease was 28.54(14.21), and for patients with sarcoidosis was 50.92(31.30). There was a statistically significant difference of serum angiotensin converting enzyme levels between patients with sarcoidosis and Behcet disease. (2 sample t-test p = 0.002) The mean(SD) of serum lysozyme level for patients with Behcet disease was 13.50(5.61), and for patients with sarcoidosis was 20.83(6.71). There was a statistically significant difference of serum lysozyme levels between patients with sarcoidosis and Behcet disease. (Mann Whitney U test p = 0.000)
Conclusions: :
The results suggest that serum levels of angiotensin converting enzyme and lysozyme are more significant for sarcoidosis with active ocular maifestations than Behcet disease with ocular involvement. The serum lysozyme level is more significant than serum angiotensin converting enzyme level for patients with active ocular involvement of sarcoidosis.
Keywords: uveitis-clinical/animal model