March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Structural Changes of the Choroid in Sarcoid-Related Granulomatous Panuveitis
Author Affiliations & Notes
  • Lola E. Lawuyi
    Moorfields Eye Hospital, London, United Kingdom
  • Pearse A. Keane
    NIHR Biomed Resrch Ctr for Opht, Moorfields Eye Hosp NHS Fndtn Trust, London, United Kingdom
  • Javier Z. Ventura
    Moorfields Eye Hospital, London, United Kingdom
  • Dawn A. Sim
    Medical Retina,
    Moorfields Eye Hospital, London, United Kingdom
  • Catherine A. Egan
    Medical Retina,
    Moorfields Eye Hospital, London, United Kingdom
  • Praveen J. Patel
    Moorfields Eye Hospital, London, United Kingdom
    NIHR Biomedical Research Centre, Uk, United Kingdom
  • Mark Westcott
    Moorfields Eye Hospital, London, United Kingdom
  • Richard W. Lee
    NIHR Biomedical Research Centre, Uk, United Kingdom
    School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
  • Adnan Tufail
    Ophthalmology,
    Moorfields Eye Hospital, London, United Kingdom
  • Carlos Pavesio
    Moorfields Eye Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships  Lola E. Lawuyi, None; Pearse A. Keane, None; Javier Z. Ventura, None; Dawn A. Sim, None; Catherine A. Egan, None; Praveen J. Patel, None; Mark Westcott, None; Richard W. Lee, None; Adnan Tufail, None; Carlos Pavesio, None
  • Footnotes
    Support  "NIHR-National Institute for Health Research, Fight for Sight"
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1194. doi:
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      Lola E. Lawuyi, Pearse A. Keane, Javier Z. Ventura, Dawn A. Sim, Catherine A. Egan, Praveen J. Patel, Mark Westcott, Richard W. Lee, Adnan Tufail, Carlos Pavesio; Structural Changes of the Choroid in Sarcoid-Related Granulomatous Panuveitis. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1194.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To characterize retinal and choroidal structure in the maculae of patients with sarcoid-related panuveitis using spectral domain optical coherence tomography (OCT).

 
Methods:
 

Patients with a known diagnosis of sarcoid-related granulomatous panuveitis were scanned using custom enhanced depth imaging (EDI) protocols (Spectralis, Heidelberg Engineering, Germany). Each image set consisted of seven OCT B-scans obtained in a 20 x 15 degree horizontal raster pattern, and with each individual B-scan generated from 50 averaged scans. Manual segmentation of retinal and choroidal layers (including Haller’s large vessel and Sattler’s medium vessel layers) was then performed using custom image analysis software. Visual acuity (VA), disease activity, and treatment modality were correlated with OCT findings.

 
Results:
 

Thirteen eyes from thirteen subjects were evaluated. Mean patient age was 51.6 years (range: 31-70), with a male : female ratio of 9:4. There were six Asian-Indian, six Afro-Caribbean, and one undeclared subject. At the time of scanning, six patients required treatment with oral steroid or steroid-sparing agents, while seven patients were treated solely with topical steroids. Five subjects had active disease, while eight were quiescent. Mean VA was 95.8 +/- 5.72 EDTRS letters. Mean retinal thickness was 281.7 mm, mean retinal volume 9.83 mm3, mean choroidal thickness 300.6 mm, and mean choroidal volume 10.5 mm3. Mean volume of Haller’s layer was 4.2mm3. An increased ratio of Haller’s layer to the choroid as a whole was significantly associated with reduced VA (r = 0.76, p = 0.004) in all patients.

 
Conclusions:
 

Evaluation of choroidal structure using specialized OCT scanning protocols may provide new insights into diffuse granulomatous uveitic disorders such as sarcoidosis, with changes in Haller’s layer providing clinically useful information about diagnosis and treatment monitoring.  

 
Keywords: uveitis-clinical/animal model • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • choroid 
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