March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Reduction of Visual Acuity in Idiopathic Panuveitis is Associated with Thinning of Sattler’s Medium Vessel Layer of the Choroid
Author Affiliations & Notes
  • Andrew Scott
    Moorfields Eye Hospital, London, United Kingdom
    UCL Institute of Ophthalmology, London, United Kingdom
  • Javier Zarranz-Ventura
    Moorfields Eye Hospital, London, United Kingdom
  • Pearse A. Keane
    Moorfields Eye Hospital, London, United Kingdom
  • Dawn A Sim
    Moorfields Eye Hospital, London, United Kingdom
    UCL Institute of Ophthalmology, London, United Kingdom
  • Catherine Egan
    Moorfields Eye Hospital, London, United Kingdom
  • Praveen J Patel
    Moorfields Eye Hospital, London, United Kingdom
  • Richard W. Lee
    Moorfields Eye Hospital and University of Bristol, London/Bristol, United Kingdom
    NIHR Biomedical Research Centre, London, United Kingdom
  • Adnan Tufail
    Moorfields Eye Hospital, London, United Kingdom
  • Carlos Pavesio
    Moorfields Eye Hospital, London, United Kingdom
    NIHR Biomedical Research Centre, London, United Kingdom
  • Mark Westcott
    Moorfields Eye Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships  Andrew Scott, None; Javier Zarranz-Ventura, None; Pearse A. Keane, None; Dawn A Sim, None; Catherine Egan, None; Praveen J Patel, None; Richard W. Lee, None; Adnan Tufail, None; Carlos Pavesio, None; Mark Westcott, None
  • Footnotes
    Support  NIHR - National Institute for Health Research, Fight for Sight
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1197. doi:
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      Andrew Scott, Javier Zarranz-Ventura, Pearse A. Keane, Dawn A Sim, Catherine Egan, Praveen J Patel, Richard W. Lee, Adnan Tufail, Carlos Pavesio, Mark Westcott; Reduction of Visual Acuity in Idiopathic Panuveitis is Associated with Thinning of Sattler’s Medium Vessel Layer of the Choroid. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1197.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To characterize chorioretinal changes in the maculae of patients with idiopathic panuveitis using enhanced depth imaging (EDI) optical coherence tomography (OCT).

 
Methods:
 

Data from Spectral domain EDI OCT images (Spectralis, Heidelberg Engineering, Germany) were retrospectively collected from patients diagnosed with idiopathic panuveitis. Images were obtained using custom EDI scanning protocols (each image set consisted of 7 OCT B-scans obtained in a 20 x 15 degree horizontal raster pattern, and with each individual B-scan generated from 50 averaged scans). Quantitative segmentation of the retina and choroidal layer was performed for each case. The choroidal layer was further segmented into Haller’s large vessel and Sattler’s medium vessel layers. Visual acuity was correlated with OCT findings using Spearman’s rank correlation coefficient.

 
Results:
 

Eight eyes from eight subjects with quiescent idiopathic panuveitis were evaluated. Qualitative analysis showed thinning the choroid, in particular Sattler’s medium vessel layer. EDI OCTs showed a mean retina thickness of 406.4 +/- 63.2 mm, and mean choroidal thickness of 252.0 +/- 50.5 mm. The ratio of retinal:choroidal thickness in the total scanned area was strongly correlated with visual acuity (r=-0.862, p=0.006), as was retinal:choroidal intensity (r=0.946, p=0.0004). Total choroidal:Haller’s layer thickness ratios were not significantly correlated with visual acuity in the whole scan area (r=0.587, p=0.126), but correlated in the foveal region (EDTRS area 9) (r=0.707, p=0.05). Total choroidal:Haller’s layer intensity ratios were significantly correlated in both total scan area as well as in the fovea (r=0.874, p=0.004) (r=0.826, p=0.01).

 
Conclusions:
 

EDI OCT of patients with idiopathic panuveitis showed thinning of the choroid, in particular, Sattler’s medium vessel layer. This strongly correlated with visual acuity, particularly in the foveal region.  

 
Keywords: uveitis-clinical/animal model • image processing • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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