March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Optical Coherence Tomography Features Of Multifocal Choroiditis
Author Affiliations & Notes
  • Praveen J. Patel
    Moorfields Eye Hospital, NIHR Biomedical Research Centre for Ophthalmology, London, United Kingdom
  • Pearse A. Keane
    Moorfields Eye Hospital, NIHR Biomedical Research Centre for Ophthalmology, London, United Kingdom
  • Dawn A. Sim
    Medical Retina,
    Moorfields Eye Hospital, London, United Kingdom
  • Javier Zarranz-Ventura
    Moorfields Eye Hospital, NIHR Biomedical Research Centre for Ophthalmology, London, United Kingdom
  • Catherine A. Egan
    Medical Retina,
    Moorfields Eye Hospital, London, United Kingdom
  • Mark C. Westcott
    Moorfields Eye Hospital, London, United Kingdom
  • Richard W. Lee
    Moorfields Eye Hospital, NIHR Biomedical Research Centre for Ophthalmology, London, United Kingdom
    School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
  • Adnan Tufail
    Ophthalmology,
    Moorfields Eye Hospital, London, United Kingdom
  • Carlos E. Pavesio
    Medical Retina Service,
    Moorfields Eye Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships  Praveen J. Patel, Allergan (R), Novartis UK (R), Topcon UK (R); Pearse A. Keane, None; Dawn A. Sim, None; Javier Zarranz-Ventura, None; Catherine A. Egan, None; Mark C. Westcott, None; Richard W. Lee, None; Adnan Tufail, Allergan (C), GSK (C), Neuronsystems (C), Novartis (C), Thrombogenics (C); Carlos E. Pavesio, None
  • Footnotes
    Support  National Institute of Health Research funding award to Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology as a Specialist Biomedical Research Centre for Ophthalmology
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1205. doi:https://doi.org/
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      Praveen J. Patel, Pearse A. Keane, Dawn A. Sim, Javier Zarranz-Ventura, Catherine A. Egan, Mark C. Westcott, Richard W. Lee, Adnan Tufail, Carlos E. Pavesio; Optical Coherence Tomography Features Of Multifocal Choroiditis. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1205. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

Multifocal choroiditis is a chronic inflammatory disorder, common in middle-aged women, characterized by multiple punched-out chorioretinal lesions at the posterior pole, and panuveitis. Comparatively little is known about the histopathologic features of this disease. In this report, we use optical coherence tomography (OCT) to evaluate the morphology of a cohort of patients with this disease.

 
Methods:
 

Clinical and imaging data were collected from patients with a diagnosis of multifocal choroiditis, attending a tertiary referral uveitis clinic over a two month period. For inclusion in the study, patients were required to have had spectral domain OCT imaging performed using "enhanced depth" protocols designed to aid choroidal visualization. All OCT image sets were obtained using a single Spectralis OCT system (Heidelberg Engineering, Germany). OCT images were qualitatively assessed for a number of retinal and choroidal features. Quantitative analyses were also performed using image analysis software. Clinical and demographic data collected included age, gender, ethnicity, visual acuity, disease status (active vs. quiescent), and current treatment.

 
Results:
 

Eight eyes (8 patients) were assessed. Mean patient age was 50 +/- 13 years. Mean logMAR visual acuity was 0.35 +/- 0.26. Three patients had "active" disease, while five patients had "quiescent" disease. Mean retinal thickness in the foveal central subfield was 294 +/-96 microns in patients with active disease and 207 +/- 85 in patients with quiescent disease. Mean choroidal thickness in the foveal central subfield was 261 +/-85 microns in patients with active disease and 222 +/- 70 in patients with quiescent disease.

 
Conclusions:
 

In patients with active multifocal choroiditis, the choroid appears thickened and the large vessels of Haller’s layer commonly appear engorged. In some patients, a thin hyporeflective layer may be seen external to the choroid consistent with fluid in the suprachoroidal space. No pathognomonic features were seen on spectral domain OCT, but future studies using long-wavelength OCT systems may address this issue by providing increased depth resolution for improved visualization of the choroid and sclera.

 
Keywords: uveitis-clinical/animal model • image processing • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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