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Cristobal A. Couto, Mauricio Martinez Cartier, Maria de las Mercedes Frick, Ariel Schlaen; Indocyanine Green Angiography Features In Vogt Koyanagi Harada Syndrome. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1207.
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To evaluate the presence of indocyianine green angiographic features in patients with Vogt Koyanagi Harada(VKH) syndrome and its clinical correlation.
Patients diagnosed with VKH disease according to the revised diagnostic criteria with good visual acuity, in a convalescent stage without inflammation, underwent an ICG angiography. ICG frames of the posterior pole were taken during the first three minutes (early phase). Moreover, the ICG background fluorescence was analized at 12 minutes (intermediate phase), and at 30 minutes (late phase).
Eighteen patients, 1 male and 17 female with a mean age of 37,4 ys ( r = 15 - 66 ), mean disease duration 4.94 ys (1-18ys) were analized. Only six patients received treatment, 3 of them Adalimumab. Fourteen out of 35 eyes ( 40%) showed a) diffuse delayed choroidal perfusion, b) multiples hypofluorescent dots and c) a fuzzy vascular pattern of large stromal vessels; signs reported in patients with active inflammation. None Adalimumab patients had ICG features.
Indocyanine green angiography can be very useful to determine the level of choroidal inflammation in patients with VKH syndrome in absence of inflammation. Adalimumab may have a better profilein the prognosis of VKH syndrome.
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