March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Structure/Function Outcomes and Correlations with Scanning Laser Polarimetry of Acute NAION
Author Affiliations & Notes
  • Mark J. Kupersmith
    Neuro-Ophthalmology, Roosevelt Hospital and NYEE, New York, New York
  • Randy H. Kardon
    Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa
  • Susan C. Anderson
    Ophthalmology & Visual Sciences, VA Medical Center & Univ of Iowa, Iowa City, Iowa
  • Mary K. Durbin
    R & D, Carl Zeiss Meditec, Inc, Dublin, California
  • Footnotes
    Commercial Relationships  Mark J. Kupersmith, None; Randy H. Kardon, None; Susan C. Anderson, None; Mary K. Durbin, Zeiss-Meditec, Inc. (E)
  • Footnotes
    Support  3U10EY017281-01A1S1 and Veterans Administration (Merit Grant; Rehabilitation Division) and Research to Prevent Blindness (New York, New York)
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1307. doi:
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    • Get Citation

      Mark J. Kupersmith, Randy H. Kardon, Susan C. Anderson, Mary K. Durbin; Structure/Function Outcomes and Correlations with Scanning Laser Polarimetry of Acute NAION. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1307.

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      © ARVO (1962-2015); The Authors (2016-present)

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To determine the potential of SLP in acute NAION for correlating with presenting visual field loss and predicting the field and retinal nerve fiber loss outcomes.


25 eyes with NAION (mean duration of vision loss 9 days at presentation) were tested with automated perimetry, SLP and OCT at baseline, 1 month and at 6 months. SLP and OCT average RNFL values for the superior and inferior arcuate regions, derived from Garway-Heath RNFL mapping, were compared to their corresponding inferior and superior visual field sensitivity.


At presentation, average SLP superior (51+16µm) and inferior (54 +9.6µm) regions were significantly worse in eyes with loss in corresponding field regions compared to eyes with normal field regions (superior 69 +4.7µm; inferior 73 +16.6µm). A significant linear relationship between SLP derived RNFL thickness and visual field sensitivity was found at baseline (r=0.32) and at 1 month (correlation r=0.55) following acute NAION. In contrast, OCT derived RNFL thickness showed no significant relationship during the same time periods when the optic nerve was still swollen. A linear correlation was found between baseline SLP derived RNFL during acute NAION and the > 6 month OCT RNFL (r=0.29).


SLP derived RNFL reduction is frequent in arcuate regions corresponding to visual field loss at presentation in eyes with acute NAION, when OCT derived RNFL shows increases from edema. SLP derived RNFL decrease seems to be an early marker for injury and permanent field and RNFL loss, while normal RNFL derived from SLP might occur in regions with potential for recovery.  

Keywords: optic nerve • imaging/image analysis: clinical • neuro-ophthalmology: optic nerve 

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