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Kazuhiko Umazume, Yoshihiko Usui, Yoko Okunuki, Takeshi Kezuka, Yoshihiro Wakabayashi, Hiroshi Goto; The role of CD14/sCD14 Costimulatory Pathway in Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1000.
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© ARVO (1962-2015); The Authors (2016-present)
The pathogenesis of diabetic retinopathy is associated with infiltration of macrophage and monocyte. CD14 is expressed mainly by macrophage and monocyte. We investigated vitreous, aqueous humor and serum levels of vascular endothelial growth factor (VEGF) and soluble CD14 (sCD14) in patients with proliferative diabetic retinopathy (PDR), diabetic macular edema (DME) and non-diabetic control.
Vitreous, aqueous humor and serum samples from 8 eyes with PDR and 11 eyes with DME and 10 eyes with control were investigated. Solule CD14 and VEGF analyzed simultaneously measured by a FACS Calibur flow cytometer.
Soluble CD14 and VEGF level of vitreous and aqueous humor were significantly higher in patients with PDR and DME than non-diabetic control (p<0.05). However, there was no difference in serum level of sCD14 and VEGF. A direct correlation between vitreous and aqueous humor was observed in PDR (r=0.66, p<0.05). A significant correlation between vitreous levels sCD14 and VEGF was observed in PDR (r=0.82, p<0.01).
Soluble CD14 may act as key regulator of producing VEGF and contributing to the pathogenesis of diabetic retinopathy.
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