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Isabel Pinilla, Elena Garcia-Martin, Emilio Abecia, Nicolas Cuenca, Miriam Idoipe, Javier Ascaso, Pilar Calvo; Cirrus And Spectralis Fourier-domain Oct In Epiretinal Membranes: Reproducibility And Ability To Detect Retinal Alterations. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1020.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the ability of Fourier-domain (FD) optical coherence tomography (OCT) to detect retinal alterations in epiretinal membrane (ERM) eyes. To test the intra-session reproducibility of macular thickness measurements in ERM and healthy subjects using Cirrus and Spectralis OCT.
Two hundred and nine of 209 subjects (87 ERM patients and 122 healthy subjects) underwent three macular scans by the same experienced examiner using the Cirrus and Spectralis OCT technologies. Differences between healthy and ERM eyes were studied. The relationship between average thicknesses with both instruments was evaluated. Repeatability was studied by intra-class correlation coefficients and coefficients of variation (COV) for the nine areas corresponding to the Early Treatment Diabetic Retinopathy Study.
Macular thickness increase was detected in ERM eyes for all OCT parameters (p<0.05). Macular average thickness was 338.45 and 431.99 µm in ERM eyes using Cirrus and Spectralis, respectively. Changes in the morphology of the retinal layers were detected using both OCTs. Macular average thickness in ERM eyes as determined by both OCTs was correlated (r= 0.678; p<0.001), but differences were statistically significant (p=0.044). In ERM eyes, measurements showed a mean COV of 2.96% using Cirrus, 2.21% using Spectralis and 0.99% using Spectralis progression feature. Intra-class correlation coefficients were higher than 0.919.
Significant differences exist in macular thickness measurements between Cirrus and Spectralis despite the high correlation of measurements between the two instruments. Fourier-domain OCT can be considered a valid device to detect alterations in ERM patients.
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