April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Increased Ischemic Index Correlates with Neovascularization in Diabetic Retinopathy
Author Affiliations & Notes
  • Adriana M. Ramirez
    Ophthalmology, UCLA Jules Stein Eye Institute, Los Angeles, California
  • Gad Heilweil
    Ophthalmology, UCLA Jules Stein Eye Institute, Los Angeles, California
  • Steven D. Schwartz
    Ophthalmology, UCLA Jules Stein Eye Institute, Los Angeles, California
  • Jean-Pierre Hubschman
    Ophthalmology, UCLA Jules Stein Eye Institute, Los Angeles, California
  • Scott Oliver
    Ophthalmology, UCLA Jules Stein Eye Institute, Los Angeles, California
  • Irena Tsui
    Ophthalmology, UCLA Jules Stein Eye Institute, Los Angeles, California
  • Footnotes
    Commercial Relationships  Adriana M. Ramirez, None; Gad Heilweil, Allergan (C); Steven D. Schwartz, Allergan, Genentech (C); Jean-Pierre Hubschman, None; Scott Oliver, None; Irena Tsui, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 1037. doi:
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    • Get Citation

      Adriana M. Ramirez, Gad Heilweil, Steven D. Schwartz, Jean-Pierre Hubschman, Scott Oliver, Irena Tsui; Increased Ischemic Index Correlates with Neovascularization in Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1037.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To study angiographic retinal non-perfusion in diabetic retinopathy (DR) and explore its association with retinal neovascularization.

 
Methods:
 

Retrospective, observational case series. An imaging database of angiograms performed at a single academic institution was searched for patients with the diagnosis of DR. Ultra wide field fluorescein angiograms were graded with a previously published protocol for quantifying retinal non-perfusion by calculating an ischemic index (ISI), the presence of retinal neovascularization, and the presence of angiographic macular leakage. Charts were reviewed for demographic and clinical information.

 
Results:
 

Twenty seven patients were identified and 42 eyes studied; mean patient age was 63 years (SD 22, range 25-92). The mean ISI in all eyes was 34.81% (SD 27, range 1-99). The mean ISI in non-proliferative DR eyes was 15% +/- 21% (range 0%-74%). The mean ISI in proliferative DR eyes was 49% +/- 21% (range 21%- 98%). Increasing ISI was significantly correlated to retinal neovascularization (p>0.0001). An ISI>21% was 100% sensitive and 83% specific for the presence of retinal neovascularization

 
Conclusions:
 

Ultra wide field fluorescein angiography provides visualization of retinal non-perfusion in eyes with DR. Eyes which had retinal neovascularization at the time of the angiography were found to have significantly larger areas of retinal non perfusion as evidenced by a higher ISI compared to eyes without retinal neovascularization.

 
Keywords: diabetic retinopathy • ischemia • edema 
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