April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Radiation And Retinal Vascular Caliber: Finding From Atomic Bomb Survivors
Masahide Yanagi; Kazuo Neriishi; Ryo Kawasaki; Eiji Nakashima; Saeko Fujiwara; Masazumi Akahoshi; Ikuno Takahashi; Tomoko Yokoyama; Tien Y. Wong; Yoshiaki Kiuchi
Author Affiliations & Notes
  • Masahide Yanagi
    Centre for Eye Research Australia, University of Melbourne, East Melbourne, Australia
  • Kazuo Neriishi
    Radiation Effects Research Foundation, Hiroshima, Japan
  • Ryo Kawasaki
    Centre for Eye Research Australia, University of Melbourne, Oakleigh East, Australia
  • Eiji Nakashima
    Radiation Effects Research Foundation, Hiroshima, Japan
  • Saeko Fujiwara
    Radiation Effects Research Foundation, Hiroshima, Japan
  • Masazumi Akahoshi
    Radiation Effects Research Foundation, Hiroshima, Japan
  • Ikuno Takahashi
    Radiation Effects Research Foundation, Hiroshima, Japan
  • Tomoko Yokoyama
    Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan
  • Tien Y. Wong
    Centre for Eye Research Australia, Melbourne, Australia
  • Yoshiaki Kiuchi
    Ophthalmology & Visual Science, Hiroshima University, Minami-Ku, Japan
  • Footnotes
    Commercial Relationships  Masahide Yanagi, None; Kazuo Neriishi, None; Ryo Kawasaki, None; Eiji Nakashima, None; Saeko Fujiwara, None; Masazumi Akahoshi, None; Ikuno Takahashi, None; Tomoko Yokoyama, None; Tien Y. Wong, None; Yoshiaki Kiuchi, None
  • Footnotes
    Support  The Ministry of Education, Culture, Sports, Science and Technology (MEXT) KAKENHI (20791254)
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 1040. doi:
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      Masahide Yanagi, Kazuo Neriishi, Ryo Kawasaki, Eiji Nakashima, Saeko Fujiwara, Masazumi Akahoshi, Ikuno Takahashi, Tomoko Yokoyama, Tien Y. Wong, Yoshiaki Kiuchi; Radiation And Retinal Vascular Caliber: Finding From Atomic Bomb Survivors. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1040.

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Abstract

Purpose: : We previously reported a relationship between estimated radiation dose and increase in the prevalence of cardiovascular risk factors among atomic bomb (A-bomb) survivors. In this report, we examined the relationship between radiation dose and retinal vascular caliber, a marker of microvascular disease, among the same sample in Hiroshima and Nagasaki, Japan.

Methods: : This is a cross-sectional study of 1,236 adults who were performed retinal photography during 2006-08. Radiation dose in eye was estimated using Dosimetry System 02 (DS02) accounting for distance from hypocenter and shielding situation during the bombing. Retinal arteriolar and venular calibers were measured from digitized retinal images using a computer-assisted program as the central retinal artery and vein equivalent (CRAE and CRVE).

Results: : Participants with eye dose of less than 0.005Gy (mean±standard deviation of CRAE 131.1±15.0µm and CRVE 196.5±20.8µm) were similar to those with radiation dose more than 0.005Gy (131.1±15.4µm and 196.8±20.8µm, respectively). There was no relationship in CRAE and CRVE with increasing radiation dose - changes in retinal caliber per 1Gy increase in radiation dose, after adjusting for age, gender, and study sites, were -0.44µm (95% confidence interval [CI]: -1.53 to 0.66; p= 0.43) for CRAE and -0.95µm (95%CI:-2.44 to 0.53; p=0.21) for CRVE, respectively. In a multivariable adjusted model, higher systolic blood pressure was associated with narrower CRAE (mean difference: -12.8µm per 100mmHG increase; 95% CI: -17.6 to -8.0 µm; P<0.001), and higher CRP was associated with wider CRVE (mean difference: 3.36 µm per mg/L; 95% CI: 1.03 to 5.70 µm; P=0.005).

Conclusions: : We did not observe significant direct association between estimated radiation dose and retinal vascular caliber changes among A-bomb survivors. However, further studies are needed for complete understanding of association between radiation and retinal vascular abnormality.

Keywords: retina • radiation damage: light/UV 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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