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Masahide Yanagi, Kazuo Neriishi, Ryo Kawasaki, Eiji Nakashima, Saeko Fujiwara, Masazumi Akahoshi, Ikuno Takahashi, Tomoko Yokoyama, Tien Y. Wong, Yoshiaki Kiuchi; Radiation And Retinal Vascular Caliber: Finding From Atomic Bomb Survivors. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1040.
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© ARVO (1962-2015); The Authors (2016-present)
We previously reported a relationship between estimated radiation dose and increase in the prevalence of cardiovascular risk factors among atomic bomb (A-bomb) survivors. In this report, we examined the relationship between radiation dose and retinal vascular caliber, a marker of microvascular disease, among the same sample in Hiroshima and Nagasaki, Japan.
This is a cross-sectional study of 1,236 adults who were performed retinal photography during 2006-08. Radiation dose in eye was estimated using Dosimetry System 02 (DS02) accounting for distance from hypocenter and shielding situation during the bombing. Retinal arteriolar and venular calibers were measured from digitized retinal images using a computer-assisted program as the central retinal artery and vein equivalent (CRAE and CRVE).
Participants with eye dose of less than 0.005Gy (mean±standard deviation of CRAE 131.1±15.0µm and CRVE 196.5±20.8µm) were similar to those with radiation dose more than 0.005Gy (131.1±15.4µm and 196.8±20.8µm, respectively). There was no relationship in CRAE and CRVE with increasing radiation dose - changes in retinal caliber per 1Gy increase in radiation dose, after adjusting for age, gender, and study sites, were -0.44µm (95% confidence interval [CI]: -1.53 to 0.66; p= 0.43) for CRAE and -0.95µm (95%CI:-2.44 to 0.53; p=0.21) for CRVE, respectively. In a multivariable adjusted model, higher systolic blood pressure was associated with narrower CRAE (mean difference: -12.8µm per 100mmHG increase; 95% CI: -17.6 to -8.0 µm; P<0.001), and higher CRP was associated with wider CRVE (mean difference: 3.36 µm per mg/L; 95% CI: 1.03 to 5.70 µm; P=0.005).
We did not observe significant direct association between estimated radiation dose and retinal vascular caliber changes among A-bomb survivors. However, further studies are needed for complete understanding of association between radiation and retinal vascular abnormality.
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