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Meagan O. Celmer, Joshua Priluck, Selena Fu; The Effects of Latisse on Periocular Skin Pigmentation. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1075.
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To objectively measure the effect on periocular skin pigmentation of 0.3% Bimatoprost (LatisseTM).
Twenty-one patients with no known ocular or skin disorders underwent treatment with LatisseTM applied bilaterally to the upper eyelids nightly over an 8 week period. A Minolta CR-400 chroma meter was used to measure eyelid skin pigmentation using an L* (pigmentation) and A* value (hyperemia), a decreasing value for L* indicating increased pigmentation. Readings on the cheek, temple, and forehead served as a control for each patient. Skin pigmentation measurements were obtained pretreatment and at 4 weeks after starting the medication. The differences in L* and A* value from baseline were analyzed using a one sample t test.
At 4 weeks, the mean change in overall eyelid skin pigmentation L* value was -0.141 ± 3.285 (p=0.767). The mean change in overall eyelid A* value was 0.5564 ± 2.077(p=0.070). The mean difference in upper L* value was -0.0635 ± 4.48 (p=0 .945). The mean difference in overall A* value was 1.0656 ± 2.65 (p=0.061). The mean L* value for upper lid was -0.2190 ± 1.395 (p= 0.450) and the lower lid was 0.0471 ± 1.107 (p=0.837).
Eyelid skin hyperpigmentation changes as measured by L* and hyperemia as measured by A* were noted after treatment with Latisse. The changes for both L* and A* value were greater in the upper lid.
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