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Jakob Grauslund, Jesper S. Jørgensen, Anders Green, Anne Katrin Sjølie; Can Dyslipidemia Predict Proliferative Retinopathy in Type 1 Diabetic Patients?. Invest. Ophthalmol. Vis. Sci. 2011;52(14):607.
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To examine whether total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides are long-term risk factors of incident proliferative retinopathy in type 1 diabetic patients.
A total of 109 type 1 diabetic patients were identified from a population-based cohort. Of these, 26 patients (23.8%) already had proliferative diabetic retinopathy (PDR) at baseline and were thus excluded from the study, which left 83 patients in risk of incident PDR. Patients were followed for median 13.8 years (range 11.0-15.0 years). Serum levels of lipids were collected at baseline and the level of retinopathy was determined at follow-up. Patients with Early Treatment Diabetic Retinopathy Study level of 60 or more in at least one eye were classified as having PDR.
For all markers examined, patients were divided into three tertiles. For LDL cholesterol, patients in the second tertile were significantly more likely to develop PDR as compared to patients in the lower tertile (odds ratio [OR] 3.43, 95% confidence interval [CI] 1.16-10.2). The odds were even higher in multivariate analysis adjusted for age, sex, duration of diabetes and haemoglobin A1c (OR 6.75, 95% CI 1.77-25.7). On the other hand, patients in the highest tertile of LDL cholesterol were not more likely to develop PDR, and total cholesterol, HDL cholesterol and triglycerides were not associated with a higher risk of incident PDR in any model.
Moderate elevations of LDL cholesterol were associated with a 6.75-fold higher risk of incident PDR in a 14-year follow-up study of Danish type 1 diabetic patients.
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