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Wendy Stephanie JACK, Roxanne R. Crosby-Nwaobi, Bhaskar Gupta, Sobha Sivaprasad; Risk Factors Of Diabetic Retinopathy In Patients Of African Descent With Type 2 Diabetes (SEL-DRS Study). Invest. Ophthalmol. Vis. Sci. 2011;52(14):610.
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© ARVO (1962-2015); The Authors (2016-present)
To quantify the risk factors of Diabetic Retinopathy (DR) in patients of African descent with type 2 diabetes in South East London (SEL-DRS study).
The analysis cohort was made up of a sample of 433 subjects with Type 2 diabetes. The risk factors were compared between 174 with severe non-proliferative and proliferative DR and 259 with no retinopathy. Chronic kidney disease (CKD) stages were defined by the UK National Kidney Federation.
The risk factors that were more significantly associated with severe DR were longer duration of diabetes (19.3 years versus 8.2 years) (p= 0.000), higher mean HbA1c (p=0.000), systolic BP (p=0.03), diastolic BP (p= 0.000) and lower eGFR (p=0.000). When patients with no retinopathy for more than 10 years were compared to those with severe retinopathy, the risk factors that remained significant was systolic BP (p=0.02) and eGFR (p=0.000). All stages of CKD were more significant in patients with severe DR than those with no retinopathy.
High systolic BP and lower eGFR are significant risk factors for severe DR in patients of African descent.
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