April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
A Single Application Sustained Release Matrix Metalloproteinase Inhibitor At A Low Dose Is Superior To Mitomycin C In Prolonging Bleb Survival
Author Affiliations & Notes
  • Alastair Lockwood
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital & UCL Institute of Ophthalmology, London, United Kingdom
    School of Pharmacy, University of London, London, United Kingdom
  • Sumit Dhingra
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital & UCL Institute of Ophthalmology, London, United Kingdom
    School of Pharmacy, University of London, London, United Kingdom
  • Hala Fadda
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital & UCL Institute of Ophthalmology, London, United Kingdom
    School of Pharmacy, University of London, London, United Kingdom
  • Anja Vetter
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital & UCL Institute of Ophthalmology, London, United Kingdom
    School of Pharmacy, University of London, London, United Kingdom
  • Ashkan Khalili
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital & UCL Institute of Ophthalmology, London, United Kingdom
    School of Pharmacy, University of London, London, United Kingdom
  • Steve Brocchini
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital & UCL Institute of Ophthalmology, London, United Kingdom
    School of Pharmacy, University of London, London, United Kingdom
  • Peng T. Khaw
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital & UCL Institute of Ophthalmology, London, United Kingdom
  • Footnotes
    Commercial Relationships  Alastair Lockwood, None; Sumit Dhingra, None; Hala Fadda, None; Anja Vetter, None; Ashkan Khalili, None; Steve Brocchini, WO09/063222 (P); Peng T. Khaw, WO09/063222 (P)
  • Footnotes
    Support  Medical Research Council G801650, Fight for Sight, Freemasons Grand Charity, NIHR Biomedical Research Centre for Ophthalmology, Helen Hamlyn Trust
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 616. doi:
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      Alastair Lockwood, Sumit Dhingra, Hala Fadda, Anja Vetter, Ashkan Khalili, Steve Brocchini, Peng T. Khaw; A Single Application Sustained Release Matrix Metalloproteinase Inhibitor At A Low Dose Is Superior To Mitomycin C In Prolonging Bleb Survival. Invest. Ophthalmol. Vis. Sci. 2011;52(14):616.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : The application of a matrix metalloproteinase inhibitor (MMPi) is a potential non-toxic alternative to mitomycin C (MMC) for prolonging bleb survival in glaucoma surgery. Previous studies in our group have shown promise using a higher dose (2.3 mg) of a sustained release excipientless tablet of ilomastat, an MMPi (IOVS 2008;49: E-Abstract 4538). In this in vivo study, we determined whether a low dose tablet was able to achieve a similar therapeutic effect.

Methods: : A randomised, prospective, masked, single observer in vivo study over 30 days was conducted. Glaucoma filtration surgery was performed on 28 New Zealand White rabbits. The rabbits received perioperatively one of four potential subconjunctival treatments, randomised according to a Latin Square

Results: : The ilomastat 1 mm (0.5 mg) treated rabbits had blebs that all survived to day 30. The ilomastat 2 mm (1 mg) group all survived until day 27 and 86 % (6) to day 30. Of the MMC treated group 29 % (2) had successful blebs at day 30, and of the ethylcellulose treated group 43 % (3) had successful blebs at day 30. The differences in bleb survival between the ilomastat 1mm and ethylcellulose tablets, and the ilomastat 1 mm and MMC groups were statistically significant (log rank P = 0.0221 and 0.0078 respectively).

Conclusions: : A low dose (0.5 mg) of ilomastat appears to be as successful in bleb survival as the higher doses that have been examined. This will allow the method of drug delivery to be refined and allow easier application in the post-operative period.

Keywords: wound healing • enzymes/enzyme inhibitors • conjunctiva 
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