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Alice Grise-Dulac, Jr., Alain Saad, Damien Gatinel; Ora Waveform Analysis Of Biomechanical Properties Of The Cornea In Normal Tension Glaucoma. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1521.
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© ARVO (1962-2015); The Authors (2016-present)
To analyze the Ocular Response Analyzer (ORA) waveform of biomechanical properties of the corneas in normal tension glaucoma (NTG) patients and compare them with those of patients with primary open angle glaucoma (POAG), isolated ocular hypertension (OHT) and normal subjects (N).
37 parameters of ORA waveform, caracterizing peak 1 and 2, were measured, among wich : area (p1 and p2area, p1and p2 area1), aspect ratio (aspect1, 2, 11 and 21), downslope (dslope1, 2, 11 and 21), width (w1 and w2), height (h1 and 2), dive (dive1 and 2)… High frequency noise in region between peaks (aplhf) was also quantified. All parameters were provided by ORA device for 58 eyes of 29 patients with NTG, 85 eyes of 43 patients with chronic POAG, 57 eyes of 29 eyes with OHT and 44 eyes of 22 N subjects. Ultrasonic central corneal thickness (CCT) was also measured for each eye. ANOVA test was used for statistical analysis. A p value lower than 0.05 was considered statistically significant.
CCT was not significantly different between the 4 groups. NTG subjects had significant lower aspect1, aspect11, dive1, dslope1, dslope11, h1 and h11 but higher aplhf than normal subjects. POAG subjects had significant higher aplhf, aspect11, w1 and lower path1 than normal subjects. NTG subjects had significant lower dive1, h1, h11, p1area, p1area1, p2area and p2area1 than POAG patients. OHT subjects had similar results to normal subjects.
NTG and POAG subjects were associated with significant differences on peak 1 and higher frequency noise (aplhf) compared to normal subjects. ORA waveform analysis could be useful in early diagnosis of NTG and POAG.
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