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Jia ying Zhang, Yi qin Xiao, Ye Wen; IOP Change And The Local Subconjunctival Tenon’S Capsule Tissue Remodeling After Glaucoma Filtering Operation. Invest. Ophthalmol. Vis. Sci. 2011;52(14):627.
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To explore the local subconjunctival Tenon’s capsule tissue remodeling and the changes in IOP after glaucoma filtering operation.
Twelve New Zealand rabbits received filtering surgery on the right eyes under general anesthesia. Clinical examination was performed to evaluate the general appearance of the treated eyes and to measure the IOP . Two rabbits were sacrificed and the eyes were enucleated on day 7,14,21and the left were killed on day 28. After the eyes were fixed, paraffin section of the eyes were labeled with HE staining and the pathological morphology was observed under a microscope .
1. The Preoperative IOP was 13.83±1.80 mmHg,and the IOP was reduced in all surgical eyes(IOP=3.33± 1.55 mmHg, P<0.05=after the surgery ,last to the postoperative day 14(IOP=10.6 ± 2.22 mmHg,P<0.05);On postoperative day 17, IOP elevated, with mean IOP of 12.62±2.13 mmHg,(P>0.05). 2. Histologic analysis of the specimens was performed at the center of the sclerotomy site as indicated by the location of the iridectomy.The proliferation of fibroblast was presented ,plus increased in filtration of macrophages on postoperative day 7.The fibroblast continued to proliferate and assosciated with the diposition of collegan fibers on postoperative day 14. The fibroblasts were decreased and instead of the tight collegan fibers on postoperative day21, and subsequently, the scar was formed on postoperative day 28.
The important process in would healing and scar formation is the transdifferentiation of fibroblasts to myofibroblasts (MFs). The changes in IOP are in accord with this process and so IOP was a key parameter to evaluate a surgery or therapy for glaucoma treatment
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