April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Repeatability of Diurnal Intraocular Pressure Parameters Over Time in Healthy Subjects
Author Affiliations & Notes
  • Kenneth B. Mitchell
    Ophthalmology, West Virginia University Eye Institute, Morgantown, West Virginia
  • Robert N. Weinreb
    Hamilton Glaucoma Center, Univ of California-San Diego, La Jolla, California
  • Tony Realini
    Ophthalmology, WVU Eye Institute, Morgantown, West Virginia
  • Footnotes
    Commercial Relationships  Kenneth B. Mitchell, None; Robert N. Weinreb, None; Tony Realini, None
  • Footnotes
    Support  NIH Grants EY015682 and EY018859 and an unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 660. doi:https://doi.org/
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    • Get Citation

      Kenneth B. Mitchell, Robert N. Weinreb, Tony Realini; Repeatability of Diurnal Intraocular Pressure Parameters Over Time in Healthy Subjects. Invest. Ophthalmol. Vis. Sci. 2011;52(14):660. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Diurnal intraocular pressure (IOP) evaluation is commonly performed to determine key parameters such as mean, peak and range of IOP. How well does a single-day IOP curve characterize diurnal IOP parameters on future days?

Methods: : Post hoc analysis of prospectively collected data. Thirty-six healthy subjects underwent Goldmann tonometry at 0800, 1000, 1200, 1400, 1600 and 1800 hrs on five days: baseline and one week, one month, six months and twelve months later. Mean, peak and range of IOP were determined at each of the five visits. The coefficient of determination (r2) was calculated for the comparison of baseline values to each subsequent value.

Results: : For mean IOP, the coefficients of determination comparing baseline to 1 week, 1, month, six months and 12 months ranged from 0.511-0.668. For peak IOP, the coefficients of determination comparing baseline to 1 week, 1, month, six months and 12 months ranged from 0.562-0.696. For range of IOP, the coefficients of determination comparing baseline to 1 week, 1, month, six months and 12 months ranged from 0.026-0.238.

Conclusions: : Mean IOP and peak IOP determined by single-day diurnal IOP evaluation correlated modestly with mean and peak IOP on subsequent days. IOP range determined by single-day IOP evaluation correlated poorly with IOP range on subsequent days. Single-day diurnal IOP assessment may not fully characterize clinically relevant diurnal IOP parameters in healthy subjects.

Keywords: circadian rhythms • intraocular pressure 
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