April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Influence Of Antiglaucoma Medication On Dynamic Contour Tonometry And Goldmann Applanation Tonometry Measurements In A Glaucoma And Ocular Hypertensive Population
Argyrios Tzamalis; Myron Kynigopoulos; Nikolaos Chalvatzis; Ioannis Tsinopoulos; Torsten Schlote; Stavros Dimitrakos
Author Affiliations & Notes
  • Argyrios Tzamalis
    2nd Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Ophthalmology Clinic Pallas, Olten, Switzerland
  • Myron Kynigopoulos
    Vedis Eye Laser Centre, Ophthalmology Clinic Pallas, Zurich, Switzerland
  • Nikolaos Chalvatzis
    2nd Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • Ioannis Tsinopoulos
    2nd Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • Torsten Schlote
    Outpatient Clinic of Ophthalmology Ambimed, Basel, Switzerland
  • Stavros Dimitrakos
    2nd Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • Footnotes
    Commercial Relationships  Argyrios Tzamalis, None; Myron Kynigopoulos, None; Nikolaos Chalvatzis, None; Ioannis Tsinopoulos, None; Torsten Schlote, None; Stavros Dimitrakos, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 683. doi:
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      Argyrios Tzamalis, Myron Kynigopoulos, Nikolaos Chalvatzis, Ioannis Tsinopoulos, Torsten Schlote, Stavros Dimitrakos; Influence Of Antiglaucoma Medication On Dynamic Contour Tonometry And Goldmann Applanation Tonometry Measurements In A Glaucoma And Ocular Hypertensive Population. Invest. Ophthalmol. Vis. Sci. 2011;52(14):683.

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Abstract

Purpose: : The aim of this study was to evaluate the effect of different IOP-lowering medications on dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) measurements in a glaucoma and ocular hypertensive population.

Methods: : In this prospective cross-sectional study, 410 eyes from 225 consecutive patients with open angle glaucoma (OAG, 280 eyes), or ocular hypertension (OHT, 130 eyes), were enrolled. All patients included in the study received the same antiglaucoma agents for at least 6 months prior to IOP measurement. All eyes underwent GAT and after a rest period of 5 minutes 3 DCT measurements alternating between right and left eye.

Results: : The DCT-GAT difference (DifDCT-GAT) did not differ statistically significantly (p=0.49) between OAG and OHT group yielding a mean ± SD of 4.26±2.02 mm Hg and 4.41±2.25 mm Hg respectively.Central corneal thickness (r = 0.004 p = 0.94), corneal curvature (r = 0.09, p= 0.11), Cup to Disc Ratio (r = -0.016 p= 0.75) and spherical equivalent (r = -0.068, p = 0.17) did not indicate any correlation with the DCT-GAT difference. The number of IOP-lowering agents did not have any statistically significant influence on DifDCT-GAT (F=1.738, p=0.177), DCT (p=0.28) and GAT (p=0.13) measurements. A statistically higher DifDCT-GAT was revealed in monotherapy patients receiving Carboanhydrase Inhibitors{CIs} (Dif DCT-GAT=5.75 mm Hg) in comparison to patients receiving Prostaglandin Analogs (Dif DCT-GAT=4.09 mm Hg) or beta Blockers (Dif DCT-GAT=3.78 mm Hg) as single topical therapy (ANOVA, F=4.373, p=0.005). Eyes treated with CIs as a part of the antiglaucoma therapy yielded a significantly greater DifDCT-GAT (Mann-Whitney-test, p=0.0035) than those without CIs in the therapeutical schema, whether DCT and GAT remained unaffected (p=0.72 and p=0.26 respectively).

Conclusions: : The difference between DCT and GAT IOP measurements is found to be statistically significantly higher in patients receiving CIs either as monotherapy or as part of multiple antiglaucoma medications, whether DCT and GAT readings remain unaffected. The glaucoma type and number of antiglaucoma medications is proved to have no statistically significant influence on the DifDCT-GAT.

Keywords: intraocular pressure • clinical (human) or epidemiologic studies: systems/equipment/techniques • carbonic anhydrase 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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